Ryze releases a runic blast, dealing magic damage. It splits in two, dealing 0.33% of the damage to the closest two enemies. Each secondary blast splits an additional time.

• Bilgewater — blasts explode on impact, dealing % as Physical Damage to adjacent enemies.
• Demacia — Execute targets below % (ArmorMR).
• Freljord — Chill targets for a few seconds and deal bonus true damage.
• Ionia — Blasts split an additional time.
• Ixtal — Gain a random Region's effect on combat start and every 10 seconds.
• Noxus — Blasts now pierce targets, dealing % reduced damage per enemy hit.
• Piltover — Every third cast is Overcharged, dealing % more damage.
• Shadow Isles — Increase blast damage by X Souls.
• Shurima — Knock up enemies with a chance to dredge up Gold or Treasures.
• Targon — Heal the lowest ally for % of the damage dealt.
• Void — Ignore % of enemies' Armor and Magic Resistance.
• Yordle — Shrink targets hit, lowering their damage by % for a few seconds.
• Zaun — Poison targets, dealing Magic Damage over a few seconds.