Set the automatic-use condition for buffs to In Combat to help avoid spending consumables unnecessarily.
Be aware that pressing left-click to attack can still trigger buff scrolls, even if you are only preparing to fight. This is particularly worth watching with melee controls.
In Info Display, consider hiding player nameplates, spirit names and nameplates, and pets. Reducing these extra elements can help with performance and make busy encounters easier to read.
Enable the boss orientation indicators if you want a clearer view of the boss’s front and back. They can help you position for attacks, although they may not appear on world bosses.
If floating combat numbers make it difficult to see what is happening, turn off Floater Display. This is a visibility preference, so keep it enabled if you find the feedback useful.
Once you have reduced the clutter, our Aion 2 HUD preset guide explains how to arrange interface elements and save your layout.