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Borderlands 4 Build

Harlowe Instant Melts Endgame

presentationHarlowe
presentationCHROMA Accelerator
End Game
Updated on Oct 25, 2025
Oct 25, 2025

Build Overview

This is a very straight forward and on incredibly strong Harlowe endgame build, focusing entirely on buffing CHROMA Accelerator. To take advantage of the very busted Neutron Capture augment. It is unbelievably insane, converting a portion of the damage dealt by your CHROMA Accelerator into flat added bonus radiation damage. This means any gun damage you deal after using your action skill will do large amounts of radiation damage, assuming your action skill hits enemies. This means if you're using a super fast firing weapon, you can deal this damage over 30x a second. It is very important to play around the CHROMA Accelerator due to Neutron Capture.


Leveling Build

Strengths And Weaknesses

  • Instant Boss Melts
  • Super fun to play
  • Nukes the entire screen
  • Damage is reliant on CHROMA Accelerator via Neutron Capture

Build Variants

Skill Tree

Points Spent 0 / 49
LMB Allocate
RMB Unallocate
CHROMA Accelerator
1/5
5/5
5/5
1/1
3/3
5/5
5/5
5/5
3/3
1/5
5/5

Equipment

Weapons
Repkits & Ordnance
Utilities

Item locations posted at the bottom

Guns:
Tons of weapons work very well due to the most recent patch changing how Neutron Capture is calculated. Katagawa's Revenge no longer works unfortunately as a result of this change.

Here's a list of some good options:

Luty Madlad w/ shotgun underbarrel (bossing)
Wombo Combo bossing & mobbing
Lucian's Flank bossing & mobbing
Purple Vladof SMG 'boory' preferably with x2 underbarrel, bossing & mobbing


Repkit: Can use a legendary Shiny War Paint as well for movement speed/rate of fire. For bossing you could use one with enrage + elemental affinity or something like that but you honestly can use anything. I think Triple Bypass could be BiS depending on the rolls but I don't have a good one

Class Mod:
All rounder and my preferred option: Skeptic with preferably +5 into Indiscrete Math or Bright Future is fine too. This will work regardless of your skill tree.

Scientist is another great option, but with the most recent patch it doesn't work as well anymore

Bossing: Reactor is best but the extra damage is honestly unnecessary - try to get +5 into Decoherence

Shield:

My preferred shield is Watts 4 Dinner
Firewerks is good for mobbing but kinda unnecessary IMO
Protean Cell is good for bossing w/ the 50% dmg buff
Watts 4 Dinner is a good all arounder if it rolls with 'Siphon'
Super Soldier is great for movement speed, the ammo regen is a little weak but it does SOMETHING
Pandoran Momento is crazy for defense

Enhancement:
When using Luty Madlad you want a Daedalus enhancement with 50% fire rate stacking.
When using a vladof gun look for a vladof enhancement w/ fire rate & mag size and/or bullet hose
When using a Jakobs gun for mobbing just try to get bounce pass
Stats: Mag Size, Sniper Mag Size SMG Mag Size, Fire Rate, SMG Fire Rate, Splash damage, Gun damage,

Firmware: Generically best setup would be:
2 Action Fist 2 GOOJFC 1 Bullets to Spare


Ordnance: Penetrator Augment knife OP as always

Guns:
Luty Madlad = Mimicron, Order Bunker, Tipping Point
Lucian's Flank = Saddleback, Ripper Drill Site, The Old Scrape


Class Mod:
Scientist = Radix, Arch of Radix, Carcadia Burn
Skeptic = Queen Callis, Her Flaming Vision, Moon-Called Throne
Atomic Driver = Origo, Terminus Range, Arch of Origo

Shields:
Firewerks = Splashzone, Coastal Bonescape, Fadefields
Protean Cell = Fractis, Order Bunker, The Crawlcoft
Watts 4 Dinner = Origo, Terminus Range, Arch of Origo
Super Soldier = Vile Lictor, His Vile Sanctum, Umbral Foundry
Pandoran Momento = world drop


Specializations

Specialization 1I Am A Gun
Specialization 2A Honed Mind
Specialization 3Now With Caffeine
Specialization 4Riddle You This

Gameplay

1) Try to hit as many mobs with CHROMA Accelerator as possible

2) Make sure to dish out damage Neutron Capture is active

3) While waiting for your CHROMA Accelerator use your repkit to instantly restore some cooldown via Now With Caffeine, alternatively you can shoot mobs that have a status effect on them therefore taking advantage of 'Practical Skeptic'

Video Guide

Table of Contents

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