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Borderlands 4 Build

Harlowe Radiation Leveling

presentationHarlowe
Leveling
presentationCHROMA Accelerator
Updated on Oct 15, 2025
Oct 15, 2025

Build Overview

This is a very straight forward and on paper super strong Harlowe leveling build, focusing entirely on radiation damage + status effect damage, with the added benefit of a pocket nuke with CHROMA Accelerator. This build will function much better when using a radiation weapon, preferably one with high status effect damage so keep that in mind while leveling. One great part about this build is that the damage is all generic and active all the time. Neutron Capture is unbelievably insane, converting a portion of the damage dealt by your CHROMA Accelerator into flat added bonus radiation damage. This means any gun damage you deal after using your action skill will do large amounts of radiation damage, assuming your action skill hits enemies. This has some insane implications for the endgame, but for the purposes of leveling, as long as you use a high rate of fire weapon (ideally a maliwan SMG) and press your CHROMA Accelerator on cooldown while hitting a few mobs with it, you'll shred everything with no problem.

It is very important to play around the CHROMA Accelerator due to Neutron Capture. Look out for any and all Action Skill Cooldown rate on gear, especially on the medkit as that will give you a ton of additional uptime on your Neutron Capture buff

This build is also by far Harlowes best endgame build, click this link to see how you'd want to set it up in endgame


Strengths And Weaknesses

  • Unbelievable Damage
  • Super fun to play
  • Damage is reliant on CHROMA Accelerator which will have a bit of a cooldown until you get some gear
  • Hard to consistently have a radiation weapon while leveling

Skill Tree

Points Spent 0 / 49
LMB Allocate
RMB Unallocate
CHROMA Accelerator
5/5
5/5
5/5
3/3
4/5
5/5
2/3
3/3
1/1

Skill Point Order:
5Cyclotron
Neutron Capture
5 Elementary
3 Enriched
2 Test Subjects or Great Red DoT (if you want more boss dps)
5 Poisoned Sun
3 Chain Reactor
2 Fissile Launcher (if using a radiation gun, if not swap to Glow Up for boss dps)
Demon Core
1 Dirty Bomb
Use the following points until level 40, at which point you will respec and put the points in above ^ and then the points posted below under 'post 40'
3 Test Subjects
5 Practical Applications
5 Field-Ready Prototype

Post 40 respec - follow the initial skill point order above the line and then this one in addition
Green:
5 Momentum or Mains Hum if you prefer defense
5 Neutron Decay
3 Confirmative Reality
3 Resonance Cascade
3 Test Subjects
4 Practical Applications - if you want more defense take Highly Efficient instead. If you want more movement speed take Get Up and Go

Gear to look out for while leveling:

Penetrator Augment which comes on Throwing Knives is EXTREMELY powerful on bosses or any tanky enemies. If you get this you can swap the 5 points from Glow Up into 3 Fissile Launcher and 2 in Periodic Table Flip

Guns: Ideally use radiation weapons, but you can use anything that's elemental and super potent as long as it is high rate of fire (smgs / vladof ar's) the higher the rate of fire = the more Neutron Capture damage you will do

Be on the lookout for the Spread Launcher, Beam Tosser, Shrapnel Cannon, Knife Launcher, Taser, or Shotgun underbarrel attachments and try them out, they are overtuned. These have internal cooldowns, you can bypass the cooldown by swapping to a different gun with the same attachment. I recommend having multiple of these and cycling between them to dish out high damage when you don't have Neutron Capture active

Repkits: 100% Action Skill Cooldown Rate, 200% Amp Damage, Lifesteal, & Movement Speed are likely the best options for smooth leveling.

Ordnance: Look out for a High Radiation DPS rocket or homing grenade

Specializations

Specialization 1I Am A Gun
Specialization 2Empty
Specialization 3Now With Caffeine
Specialization 4Empty

Gameplay

1) Try to hit as many mobs with CHROMA Accelerator as possible

2) Make sure to dish out damage Neutron Capture is active

3) While waiting for your CHROMA Accelerator use your Repkit with action skill cooldown rate. This is also a great time to use your ordnance as your actual gun damage may be low outside of Neutron Capture, or use any gun with a potent underbarrel attachment

Video Guide

Table of Contents

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