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Borderlands 4 Build

Harlow - Shockingly Radioactive - ENDGAME

End Game
presentationHarlowe
presentationCHROMA Accelerator
Updated on Sep 26, 2025
Sep 26, 2025

Build Overview

This build is a variant of NickTew's endgame Melt guide but with some various tweaks that I've found work better for me as both a mobbing and bossing build.

A lot of these builds use Katagawa's Revenge revenge for add clear but I've found Complex Root to work even better in a lot of situations.

Strengths And Weaknesses

  • Melts Bosses Extremely Fast
  • Fun to play, rainbow/yellow/blue explosions galore.
  • The crux of the damage comes from
    Neutron Capture while bossing.

Skill Tree

Points Spent 0 / 49
LMB Allocate
RMB Unallocate
CHROMA Accelerator
2/5
5/5
5/5
3/3
3/5
5/5
2/3
3/3
1/1
5/5

I've tried a fair few variances for this type of build but this spread from NickTew has worked the best for me for both types of content. Has a great mix of both raw damage and CDR for getting more CHROMA Accelerator's out.

You can change a few things to get more damage or defense out if you desire.

Equipment

Weapons
Repkit & Ordnance
Utilities

Guns:
Mobbing: Complex Root paired with Firewerks makes short work of the majority of trash mobs. You can also use Katagawa's Revenge but I'm using the legendary Malawan Enhancement called Merciless Lame.

This pairs Synthesizer and Mixologist together so having Shock and Radiation on Complex Root further increases the radiation damage done.

Lucian's Flank and Rainbow Vomit are also fun guns to use but not as powerful as the others.

Bossing: Plasma Coil with shock and radiation, for the same reasons as above, absolutely shreds bosses once you have Neutron Capture rolling. Complex Root also works extremely well but a fast firing Luty Madlad is also extremely powerful but I haven't found a decent one myself.

Repkit:
Shiny War Paint I've found works extremely well, but make sure it has the Accelerator perk on it for more cooldown reduction.

Class Mod:
The Scientist class mod makes it so any time you shock an enemy you also apply radiation AND entangle the enemy, this can stack up status effect damage extremely fast on bosses and mobs alike.

Try to get Ripple Effect and Action at a Distance +5 on it. These will spread Entanglement and status effects to mobs in the area very fast and it works well on bosses that spawn adds constantly as well.

For passives mine has +25% Action Skill Cooldown Rate and +35% Splash Damage.

Shield:
There are quite a few options for shields but personally I stick to a good rolled Firewerks with lightning resist as that allows the missiles to also apply radiation.

I have Heavy Plate on mine just for some comfy damage reduction.

If you would rather a shield that focuses on pure damage reduction than something like Pandoran Momento is very powerful.

Enhancement:
So I am currently using a legendary Malawan Enhancement called Merciless Lame. This has Synthesizer which adds +25% status effect damage, and Mixologist which adds 10% to the damage type of the inactive mode's element.

When using the guns above paired with the class mod you want to be using the Shock modes as this synergises well with everything to be constantly buffing radiation damage while also dealing a lot of shock damage at the same time.

Stats wise try to get Mag Size, Sniper/SMG Mag Size, Fire Rate, SMG Fire Rate, Splash damage or Gun damage. Any of those together will work well.

If you use Luty Madlad then you want a Daedalus enhancement with the 50% fire rate stacking buff.

Ordnance:
You probably already know what I'm going to say but yes, unfortunately, a Jakobs throwing knife with Penetrator Augment + Damage Amp Payload is by far the best choice for this slot. The sheer damage both of those debuffs add is immense and I feel like might get nerfed at some point.

If you can't find a knife with both, aim for Penetrator Augment first.

Firmware: Aim for 3pc of Deadeye paired with 2pc of Bullets to Spare.

ITEM DROP LOCATIONS:

Guns:
Complex Root - Mimicron / Order Bunker / Tipping Point
Katagawa's Revenge - Driller Hole / Tonnage Peel / Queen's Cradle
Plasma Coil - Timekeeper / Terminus District / Upper Dominion
Luty Madlad - Mimicron / Order Bunker / Tipping Point
Rainbow Vomit - Leader Willem / Grindstone of the Worthy / The Excrucible
Lucian's Flank - Saddleback / Ripper Drill Site / The Old Scrape

Class Mod:
Scientist - Primordial Guardian Radix / Vault of Radix / Grindstone of the Worthy

Shields:
Firewerks - Splashzone / Coastal Bonescape / Fadefields
Pandoran Momento - World Drop (sadly)

Repkit:
War Paint - Saddleback & Immortal Boneface / Ripper Drill Site / Cuspid Climb

Enhancement:
I'm fairly certain all enhancements are just world drops but a few people have speculated that the end of zone bosses have a higher chance to drop them. So far I've found very few legendary ones.

Ordnance:
Same as above, since this weapon isn't a legendary, there's no real way to target farm it, just farm the boss you find the fastest (for me I got my god roll from Mimicron while getting other items).

Specialization

Specialization 1I Am A Gun
Specialization 2A Honed Mind
Specialization 3Now With Caffeine
Specialization 4Riddle You This

Gameplay

Step 1: Hit Boss/As many enemies as possible with CHROMA Accelerator, you can detonate it early if it's about to pass by the boss/enemies.

Step 2: Throw your knife at boss.

Step 3: Unload your fastest firing weapon to get as much damage in as possible for the short windows of both Neutron Capture and the knife augments.

Step 4: ????

Step 5: Get loot.

While your ability is cooling down, you can use your repkit offensively to get a bunch of your cooldown back thanks to both Now With Caffeine and Accelerator.

Notes

Credit for the layout and talent point distribution goes to NickTew. His guide was by far the most neatly laid out for a CHROMA Accelerator build.

Table of Contents

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