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PoE 2 Build

0.4 Poisonburst Pathfinder Leveling Guide

presentationPathfinder
presentationRanger
Starter
0.4 TLotD
Verified
Updated on Dec 14, 2025
Dec 14, 2025

Build Overview

This is my leveling guide for Poisonburst Pathfinder, swap to the endgame guide after campaign.

You'll be leveling as poison from the very start with this build guide.

Vendor regex: "y: \+|ts: S|\d+% i.+mov|ward|phy.*att.*|uiv"
(You copy and paste this into your vendor window, to easily see items you might want to buy)

Build Variants

Equipment

item
1
item
3
item
3
item
2
item
5
item
6
item
Equipment Priority
+6

Early boss kill order for a smooth experience:
Devourer > cold witch > hut witch > rust king
Grab Concentrated Area after killing devourer and Escalating Poison as your 2nd support.

Act 1 support gem priority - Concentrated Area > Escalating Poison > Unleash > Swift Affliction I > Pierce I

To use Withering Presence in act 1 you'll need 1 piece of gear with + intelligence, it's fine if you don't meet the requirements right away as you'll get more attributes in act 2.

In act 1 it's very important to have gear with flat physical damage to attacks. At lvl 11 you want to get a Warden Bow, with %phys or flat phys. Use your free storm rune/artificer orb on the bow.

While flat elemental damage isn't ideal, it's still quite good for lvling because Toxic Growth does do a lot of hit dmg before you acquire all of your poison nodes.

Also look at the vendor in town every 1-2 lvls for flat damage gloves, every flat for the build is massive in act 1

Movement speed on boots is also extremely good if you can find them, try to search the vendor every 1-2 lvls. I would never swap out movement speed boots, only replace them with other boots that have movement speed.

Besides that you're just looking for life/resist on gear, but flat damage is the most important on gloves/rings.

!!!!Important!!!!!
Always salvage weapons with quality for whetstones and always salvage items with sockets for artificers orb, this is extremely important for gear upgrades throughout the campaign.

I also personally prefer to vendor all rares for gold to gamble in act 2 and act 3 for better gear.

Skill Gems

Support Gem Requirements:

Str 5

Dex 10

Int 10

1

Lightning Arrow

2

Poisonburst Arrow

supportescalatingpoisonplayer
supportconcentratedareaplayer
3

Contagion

supportunleashplayer
4

Vine Arrow

supportswiftafflictionplayer
5

Withering Presence

prolongeddurationsupportplayer
Gem Priority
+5

Act 1 support gem priority - Concentrated Area > Escalating Poison > Unleash > Swift Affliction I > Pierce I

When not doing bosses in act 1, swap out Escalating Poison for Pierce I on Poisonburst Arrow

Quality prio: Toxic Growth > Poisonburst Arrow > Vine Arrow > Gas Arrow
Link prio: Toxic Growth > Poisonburst Arrow > Vine Arrow > Gas Arrow

Lightning Arrow is used for lvls 1-6 to clear packs easier, combo it with Contagion
(after The cemetery zone feel free to drop LA), it doesn't need any supports.

Poisonburst Arrow is your main skill for the whole campaign, early on you combo it with Contagion as it'll spread your poison to all nearby enemies.

Vine Arrow is used for bosses or rare monsters, place it on top of the boss so poisonburst arrow will both also hit it.

Take Withering Presence as your 1st spirit gem, but you'll want to replace it in act 2 with Herald of Plague which massively improves your clear. This also allows you to drop Contagion, saving you 1 less skill to use.
Plague Bearer is also fine to take, but you will still replace it with Herald of Plague

Passive Tree

main:
123
123
set 1:
20
20
set 2:
20
20

If you're lacking attributes in act 1 than give up Vile Wounds for small attribute nodes.

In general just use dexterity for your small attribute nodes. Use strength/int if you need it for gear or support gems.

You'll likely need to use 3 small attributes nodes for intelligence early on to use Withering Presence

Ascendancy order:
Overwhelming Toxicity > Path Seeker > Running Assault

Quest Rewards

Check which quests you’ve completed on your character
Clearfell — Beira of the Rotten Pack
Not Specified1 choice
Hunting Grounds — The Crowbell
Not Specified1 choice
Freythorn — The King in the Mists
Not Specified1 choice
Ogham Farmlands — Una's Hut
Not Specified1 choice
Ogham Manor — Candlemass, the Living Rite
Not Specified1 choice
Keth — Kabala, Constrictor Queen
Not Specified1 choice
Valley of the Titans — Medallion
Not Specified2 choices
Deshar — Final Letter
Not Specified1 choice
The Spires of Deshar — Sisters of Garukhan
Not Specified1 choice
Jungle Ruins — Mighty Silverfist
Not Specified1 choice
The Venom Crypts — Venom Draught
Not Specified3 choices
Jiquani's Machinarium — Blackjaw, the Remnant
Not Specified1 choice
The Azak Bog — Ignagduk, the Bog Witch
Not Specified1 choice
The Molten Vault — The Molten Vault
Not Specified1 choice
Aggorat — Blood Sacrifice
Not Specified1 choice
Journey's End — Captain Hartlin
Not Specified1 choice
Eye of Hinekora — Navali's Rest
Not Specified1 choice
Halls of the Dead — Yama The White
Not Specified1 choice
Halls of the Dead — Tawhoa's Test
Not Specified2 choices
Abandoned Prison — Goddess of Justice
Not Specified2 choices
Halls of the Dead — Tasalio's Test
Not Specified2 choices
Halls of the Dead — Ngamahu's Test
Not Specified2 choices
Wolvenhold — Oswin, the Dread Warden
Not Specified1 choice
The Khari Crossing — Akthi and Anundr
Not Specified1 choice
The Khari Crossing — Molten Shrine
Not Specified1 choice
Qimah — Tabana's Pillar
Not Specified7 choices
Kriar Village — Lythara, the Wayward Spear
Not Specified1 choice
Howling Caves — The Abominable Yeti
Not Specified1 choice

How it Plays

Quest Rewards in Campaign

  • 1) Medallion: Increase charm charges gained
  • 2) Venom reward - Stun threshold
  • 3) Tattoo act 4 reward - Dex/Int/Fire resist(can also take str)
  • 4) Prison - life recovery from flask
  • 5) Interlude - Can choose Resist, MS or global defense (it's free to change at anytime)

Video Guide

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