Day 1
First thing you want to do is look around the map for which locations have the fire modifier. This will help you get a fire weapon early on, with sometimes a great weapon that you can use until the end of the run. If you found one but prefer a better one, you can always kill Field Bosses on day 2 for the chance at a better weapon.
After you get level 2 at the start of the run, keep clearing Forts, Cathedrals, and Encampments to grind until you have around level 8. This is the point where you can start killing field bosses, so it's the minimum level needed for day 2.
While you go around the map, check if Trolls have spawned in the central castle to make sure you know if you can go there on day 2.
If you cannot find any of the recommended weapons, try to find one of the following categories: Great Hammers, Hammers, Colossal Weapons, Colossal Swords, Curved Greatswords, or Greataxes.
Day 2
Now we want to look at the map. If we had Noklateo or the Crater spawn, we would want to go there immediately since they tend to take a while. If the Mountain or Rot Forrest spawned, we can go there later on the day. If none spawned or you feel you need to get stronger, and Trolls didn’t spawn inside the central castle, you can go there and easily hit level 12-13 from that alone. After this, you can easily do any other content and grind towards that.
Keep in mind that if a Settlement spawned, check it out. These often have a ton of good stuff you can purchase, but you do require quite a few runes to get it.
Day 3
As mentioned before, Gnoster consists of two entities: The Butterfly and the Lobster. These share the boss's HP pool but act independently. Most of the time, you will be face to face with the lobster, so let's talk about him first.
The lobster mostly has AOE attacks that are heavily delayed to make you dodge before it hits. He has two that hit in front of him, and one that hits when you are to his side.
The Butterfly mostly shoots projectiles and poison mist, do not stay inside there because this is not normal poison. You will also instantly be poisoned if you get hit by the Butterfly’s grab attack. This poison eventually grows a parasite that will hit you and stagger you consistently, ruining your fight most likely. In multiplayer, this can be cleansed by an ally hitting you with fire damage. In singleplayer, this can only be cleansed by dying.
In phase 2, most of the attacks stay the same, but now the Butterfly sits on top of the Lobster. They do have two new attacks: At the start of phase 2 and during it, the Lobster will charge forward a couple of times while the Butterfly shoots projectiles. This attack is extremely dangerous and very hard to dodge, so I recommend springing to the side the moment you see it start. The butterfly can also occasionally spawn a huge laser beam from the air that lingers quite long.