Alesh is better played with an Operator that can consistently apply Cryo to enemies, as his Battle Skill allows him to consume Cryo Inflictions to regenerate SP based on the number of Inflictions consumed and also apply Solidification to them. You also need someone to consume Arts Reactions or Endmin’s Originium Crystals. Any Physical Unit can consume Endmin’s Crystals, but they can’t apply Cryo Inflictions. Lucky for you, Estella is a 4-Star that checks both conditions.
Start with Estella’s Battle Skill to apply Cryo Infliction, use Alesh’s Battle Skill to force Solidification and trigger Estella’s Combo Skill, which consumes Solidification and triggers Alesh’s Combo Skill. It’s a perfect cycle that generates SP and applies Physical Weakness to enemies. Sure, you don’t need to play with Estella, but they both help each other and you can just fill the last two slots with whatever you want to play.
Use his Ultimate when available as it deals good Cryo DMG, applies Cryo Infliction and also recovers some SP for your team.