Note: Updated for 0.2.0g including the location of all known Artificer's Orbs, but I am still exploring and adding things as they are discovered
The Path of Exile 2 campaign is massive and knowing where to go to collect all permanent buffs as well as useful items such as Uncut Gems or Lesser Jeweller's Orbs is very hard to remember. This guide will list the location of all useful items that you can find throughout the campaign in Normal difficulty. If you're looking for the Campaign Bonuses and Rewards for Cruel, click here:PoE 2 Cruel Campaign Bonuses and Rewards
Some, but not all, Uncut Gem Quest Rewards have been included in this guide to help ensure you collect ones that are more impactful. Some possible rewards have been left out if they weren't deemed impactful enough to be noted
Act 1 Normal
ACT 1 NORMAL
Clearfell
BOSS -Beira of the Rotten Pack
+10% Cold Resistance
Mysterious Campsite
Uncut Skill Gem (Level 1)
Mud Burrow
BOSS -The Devourer
Uncut Skill Gem (Level 2) (Boss Drop)
Uncut Support Gem (Level 1), 100 Gold (Quest Reward)
The Grelwood
BOSS -The Brambleghast
Uncut Skill Gem (Level 2)
Aregane's Hut:
Medium Life and Medium Mana Flask
Uncut Support Gem (Level 1): Slay Areagne
The Red Vale
BOSS -The Rust King
Uncut Skill Gem (Level 3)
The Grim Tangle
BOSS -The Rotten Druid:
Uncut Support Gem (Level 1)
Cemetery of the Eternals
BOSS -Lachlann of Endless Lament
Uncut Skill Gem (Level 3)
Sarcophagus beside Grieving Epitaph
Normal Rarity Ring: Sarcophagus beside Grieving Epitaph
Tomb of the Consort
Haunted Treasure (Slay the Eternal Knight)
Uncut Support Gem (Level 1)
Hunting Grounds
BOSS -The Crowbell
Reward: Book of Specialisation (+2 Weapon Set Skill Points)
Complete Ritual Altar
Uncut Skill Gem (Level 4)
Dryadic Ritual
Uncut Support Gem (Level 1)
Freythorn
BOSS -The King in the Mists
+30 to Maximum Spirit
Uncut Spirit Gem (Level 4)
Ogham Farmlands
Una's Lute (inside Una's Lute Box in her hut)
Book of Specialisation (+2 Weapon Set Skill Points)
Crop Circle
Uncut Skill Gem (Level 4)
Ogham Village
BOSS -The Executioner
Uncut Support Gem (Level 1)
Uncut Skill Gem (Level 5) Quest Reward, Leitis
Renly's Workshop
Salvage Bench:Find Renly's Smithing Tools to unlock
Artificer's Orb - found in the Blacksmith's Chest behind Renly's Tools
Blank Lesser Rune - found in Blacksmith's Chest behind Renly's Tools and can be converted into a Rune of your choice at Renly
The Manor Ramparts
The Gallows
Click the rope of the noose holding the hanging man
Uncut Support Gem (Level 1)
Ogham Manor
BOSS -Candlemass, the Living Rite
+20 to Maximum Life
Act 2 Normal
ACT 2 NORMAL
Vastiri Outskirts
BOSS - Rathbreaker
Uncut Skill Gem (Level 6) - Quest Reward (Zarka)
Mawdun Quarry
Artificer's Orb - located in the Faridun War Cache beyond a bridge beside a Checkpoint
Mawdun Mine
Munitions Bunker (Environmental Object)
Uncut Skill Gem (Level 6)
Traitor's Passage
BOSS - Balbala, the Traitor
Djinn Barya (access to Trial of the Sekhema for Ascendancy)
Bell Chest (Environmental Object)
Uncut Skill Gem (Level 6)
Keth
BOSS - Kabala, Constrictor Queen
Book of Specialisation (+2 Weapon Set Skill Points)
Abandoned Prayer (Environmental Object)
Magic Amulet
The Lost City
The Ninth Treasure of Keth (Big Bug Monster)
Magic Jewel
Golden Tomb (Environmental Object)
Uncut Spirit Gem (Level 6 or 7, depending in which order you complete Act 2)
Buried Shrines
Suspicious Sarcophagus (Environmental Object)
Uncut Support Gem (Level 1)
Elemental Offering (Environmental Object)
Pick One:
Magic Ruby Ring (Offering of Fire)
Magic Sapphire Ring (Offering of Water)
Magic Topaz Ring (Offering of Lightning)
"City of the Seven Waters" Quest
Ignite the Goddess with the Everlasting Cinders and take The Essence of Water
Uncut Support Gem (Level 1)
Valley of the Titans
"Offering to Amrit" Quest
Place the Kabala Clan Relic and Sun Clan Relic
+30% increased Charm Charges Gained or 15% increased Mana Recovery from Flasks
The Titan Grotto
BOSS - Zalmarath, the Colossus
"A Crown of Stone" Quest Reward
Slay Zalmarath, the Colossus
Uncut Support Gem (Level 1)& 500 Gold
Titan's Sword (Environmental Object)
Random Lesser Rune
Mastodon Badlands
Fossilised Memorial (Environmental Object)
Uncut Support Gem (Level 1)
The Bone Pits
BOSS - Iktab, the Deathlord and Ekbab, Ancient Steed
Uncut Support Gem (Level 1)(Reward for "A Theft of Ivory" Quest)
Deshar
"Tradition's Toll" Quest Reward
Find the body of the Rhoa rider beside the base of one of the burial towers and collect the Final Letter
Book of Specialisation (+2 Weapon Set Skill Points)
Artificer's Orb - Located by clicking The Unremembered (a skeleton) in a small area beyond a Checkpoint
Rare Vulture Monsters
Slay both Rare Vulture monsters to guarantee this drop
Djinn Barya
Path of Mourning
Hushed Urn (Environmental Object)
Uncut Skill Gem (Level 8)
The Spires of Deshar
Sisters of Garukhan (Environmental Object)
+10% to Lightning Resistance
Act 3 Normal
ACT 3 NORMAL
Sandswept Marsh
Foul Ritual (Environmental Event)
Uncut Skill Gem (Level 9)
Orok Campfire (Environmental Event)
Lesser Jeweller's Orb (there is a chest in this camp that will always drop this item)
Note: This area is named "Orok Campfire" but the actual object you need to click is the "Azak Campfire" and the monsters defending it are called Azakh.
Jungle Ruins
BOSS - Mighty Silverfist
Book of Specialisation (+2 Weapon Set Skill Points)
Jungle Grave (Environmental Object)
Summon Servi to complete this quest
Rare Rawhide Belt or Linen Belt
The Venom Crypts
This area is found within the Jungle Ruins
Corpse Snake Venom (Quest)
Choose One Permanent Buff
+25% increased Stun Threshold
+30% increased Elemental Ailment Threshold
+25% increased Mana Regeneration Rate
Artificer's Orb - Servi will also give you an Artificer's Orb for completing this quest
The Azak Bog
This area is connected to The Infested Barrens.
BOSS - Ignagduk, the Bog Witch
+30 to Maximum Spirit
Chimeral Wetlands
BOSS - Xyclucian, the Chimera
Chimeral Inscribed Ultimatum(access to Trial of the Chaos for Ascendancy)
Uncut Skill Gem (Level 9)
Jiquani's Machinarium
BOSS - Blackjaw, the Remnant
+10% to Fire Resistance
Jiquani's Sanctum
Grand Soul Core Nexus (Environmental Object)
Uncut Spirit Gem (Level 10)
Paquate's Mechanism (Environmental Object)
Altar that provides the opportunity to Corrupt a single item in a way that is identical to a Vaal Orb
The Molten Vault
This area is connected to The Drowned City
BOSS - Mektul, the Forgemaster
"Treasures of Utzaal" Quest Reward
Uncut Skill Gem (Level 10)
Reforging Bench(return The Hammer of Kamasa to Oswald)
Artificer's Orb
Temple of Kopec
BOSS - Ketzuli, High Priest of the Sun
Uncut Skill Gem (Level 11)
Utzaal
BOSS - Viper Napuatzi
Uncut Support Gem (Level 2)
Perculiar Fortunes
Various Idols can be found in side areas of this zone that can be sold to Oswald in town for Gold
500 Gold: Golden Idol - Napuatzi's Quarters
1000 Gold: Grand Idol - Azcapa's Quarters
1500 Gold: Glorious Idol - Uromoti's Quarters
Aggorat
"Blood Sacrifice" Quest Reward
Place the Sacrificial Heart on the Sacrificial Altar and stab it to gain the reward. The Sacrificial Heart can be found as a random drop from Vaal Goliaths in either Utzaal and Aggorat
Book of Specialisation (+2 Weapon Set Skill Points)
Act 1 Rewards Cheat Sheet
ACT 1 Normal
Location
Reward
Clearfell: Boss (Beira)
+10% to Cold Resistance
Clearfell: Mysterious Campsite Chest
Uncut Skill Gem (Lvl 1)
Mud Burrow: Boss (The Devourer)
Uncut Skill Gem (Lvl 2)
Mud Burrow: Boss Quest Reward
Uncut Support Gem
The Grelwood: Boss (The Brambleghast)
Uncut Skill Gem (Lvl 2)
The Grelwood: Areagne's Hut
Uncut Support Gem - Slay Areagne
The Red Vale: Boss (The Rust King)
Uncut Skill Gem (Lvl 3)
Cemetery of the Eternals: Boss (Lachlann)
Uncut Skill Gem (Lvl 3)
Cemetery of the Eternals: Sarcophagus
Normal Rarity Ring
Tomb of the Consort: Haunted Chest
Uncut Support Gem
Hunting Grounds: Boss (The Crowbell)
Book of Specialisation (+2 Passive Points)
Hunting Grounds: Complete the Ritual
Uncut Skill Gem (Lvl 4)
Hunting Grounds: Dryadic Ritual
Uncut Support Gem
Freythorn: Boss (The King in the Mists)
+30 to Maximum Spirit
Freythorn: Boss (The King in the Mists)
Uncut Spirit Gem (Lvl 4)
Ogham Farmlands: Una's Lute
Book of Specialisation (+2 Passive Points)
Ogham Farmlands: Crop Circle
Uncut Skill Gem (Lvl 4)
Ogham Village: (Renly's House) Smithing Tools
Unlocks Salvage Bench
Ogham Village: Blacksmith's Chest (Renly's House)
Artificer's Orb
Blank Rune (Lesser)
Ogham Village: Boss (The Executioner)
Uncut Support Gem
Ogham Village: Save Leitis
Uncut Skill Gem (Lvl 5)
The Manor Ramparts: The Gallows
Uncut Support Gem
Ogham Manor: Boss (Candlemass)
+20 to Maximum Life
Act 2 Rewards Cheat Sheet
ACT 2 Normal
Location
Rewards
Vastiri Outskirts: Boss (Rathbreaker)
Uncut Skill Gem (Lvl 5)
Mawdun Mine: Faridun War Cache
Artificer's Orb
Traitor's Passage: Bell Chest
Uncut Skill Gem (Lvl 6)
Traitor's Passage: Boss (Balbala)
Djinn Barya
Keth: Boss (Kabala)
Book of Specialisation (+2 Passive Points)
The Lost City: Golden Tomb
Uncut Spirit Gem (Lvl 6/7)
Buried Shrines: Suspicious Sarcophagus
Uncut Support Gem
Buried Shrines: Elemental Offering
Magic Rarity Resistance Ring
The Valley of the Titans: Offering to Amrit
Charm Charges or Flask Mana Recovery
The Titan Grotto: Titan's Sword
Random Lesser Rune
Mastodon Badlands: Fossilised Memorial
Uncut Support Gem
Deshar: Locate Fallen Rhoa Rider
Book of Specialisation (+2 Passive Points)
Deshar: The Unremembered
Artificer's Orb
Spires of Deshar: Sisters of Garukhan
+10% to Lightning Resistance
Act 3 Reward Cheat Sheet
ACT 3 Normal
Sandswept Marsh: Boss, Foul Ritual
Uncut Skill Gem (Lvl 9)
Sandswept Marsh: Hanging Tree
Magic Ring
Sandswept Marsh: Azak Campfire
Lesser Jeweller's Orb
Jungle Ruins: Boss (Mighty Silverfist)
Book of Specialisation (+2 Passive Points)
Jungle Ruins: Jungle Grave
Rare Belt
The Venom Crypts: Corpse Snake Venom
Permanent Buff (Choice of Three)
The Venom Crypts: Corpse Snake Venom
Artificer's Orb
Infested Barrens: Cave Location*
Uncut Support Gem
Azak Bog: Boss (Ignagduk)
+30 to Spirit
Chimeral Wetlands: Boss (Xyclucian)
Uncut Skill Gem (Lvl 9)
Inscribed Ultimatum
Chimeral Wetlands
Access to Trial of Chaos
Chimeral Wetlands: Toxic Bloom
Magical Amulet
Jiquani's Machinarium: Boss (Blackjaw)
+10% to Fire Resistance
Jiquani's Sanctum: Vaal Pedestal*
Optional Free "Vaal Orb" mechanic
The Molten Vault: Boss (Mektul)
Unlocks Reforging Bench
The Molten Vault: Boss (Mektul)
Artificer's Orb
Utzaal: Boss (Viper Napuatzi)
Uncut Skill Gem (Level 2)
Aggorat: Blood Sacrifice
Book of Specialisation (+2 Passive Skill Points)
*indicates that the name of the encounter needs to be confirmed