Niche Keepsakes have good potential, but in limited circumstances. They will only be subbed in for the higher-ranked Keepsakes when your specific build and circumstance call for it, and are not considered go-to items.
Moon Beam
If you start a run with
Moon Beam, you're likely going to max out your
Selene Path of Stars options by the end of the run. Other than for the fun of it, you'll never need to accomplish this.
Therefore,
Moon Beam is best used when you already have a strong Hex with a high Magick Build, but need the extra Paths to get to a desired Sublime, Bright, or Godsent upgrade.
- Example: You already have
Dark Side and a
Aphrodite Core Boon, but haven't been able to upgrade path to the Godsent Allure of Aphrodite. Equip
Moon Beam next region so you can you benefit from the upgrades.
Blackened Fleece
Blackened Fleece is a niche Keepsake specific to Omega Move-focused builds. You need to have taken a total of 250 damage throughout this night to activate its effect, meaning you'll likely only be able to use it in the 3rd or 4th regions.
For builds where you spam Omega Moves, and extra 40% damage can go a long way. Typically, Blackened Fleece is saved for the final Region where your damage and Magick is at their highest, and you need the extra damage to help with the final boss.
Always check if you have passed the damage threshold because the accumulated total is calculated before any damage reduction (such as Weak Curse's 30% reduction).
Fig Leaf
When you're pressed for time, there is no better Keepsake than
Fig Leaf. At max rank, you'll skip 3 total encounters during your run. Encounters can't be final bosses, but they can be mini bosses.
Every speedrun will include
Fig Leaf as the 2nd region's Keepsake. Besides trying to achieve victory as quickly as possible, Fig Leaf is not as beneficial to your run as many other Keepsakes.
Ghost Onion
The best hidden quality of
Ghost Onion is that it is unaffected by the
Vow of Scars. Even at rank 3, where you can't be healed, Ghost Onion will still heal
Melinoë for the full amount. Additionally, when playing at super high Fear and while using the "At Fates Whim" Keepsakes,
Ghost Onion will find much more use.
Outside of these unique scenarios, you'd be better off equipping
Luckier Tooth for a Death Defiance that grants an equal amount of health plus the benefit of +1 hit. Even taking
Gold Purse and buying more than 100 healing with your Gold Crowns feels more worth it. At least Ghost Onion is guaranteed healing.
Knuckle Bones
Knuckle Bones is another Keepsake you'll primarily see used for the final boss fight. The bit of auto damage inflicted to the region's boss is nice to have, and the 10% damage reduction ain't bad either.
Considering you also only benefit from
Knuckle Bones in a single fight, and that most other Keepsakes have more universal benefits, using Knuckle Bones is not highly recommended.
Silver Wheel
Instantly gaining a considerable chunk of Magick is useful on runs where you keep running out of Magick. Even with
Vow of Hubris 2, which primes Magick with every Boon, you'll not often feel the need to equip the Silver Wheel.
The best function of the
Silver Wheel is that you keep the bonus Magick even after unequipping the Keepsake. If you have multiple Boons like
Static Shock,
Stalwart Stand, and
Snow Queen that prime large amounts of Magick, then you may want to consider throwing on Silver Wheel in the 3rd Region.
Lion Fang
Unless you get lucky and hit
Cherished Heirloom,
Lion Fang shouldn't be your first consideration. By the time you get to the region's boss, you'll have lost over half of Lion Fang's bonus damage! If you need to clear rooms faster,
Metallic Droplet,
Blackened Fleece or
Fig Leaf would be better choices.
At rank IV with
Cherished Heirloom, you start at +70% damage and will end with up to +45% going into the final boss. Otherwise, +25% damage will be less helpful than Keepsakes like
Knuckle Bones or
Luckier Tooth against the boss.