The high-tier Gods offer some great boons, but have fewer desirable options. You'll often want them in your God pool, but not always as your primary God. When using them as the foundation of a build, it takes more locations to feel their power come online compared to the top-tier Gods.
Hephaestus
Hephaestus is the best defensive God in Hades II. Equipping his Keepsake in the 2nd or 3rd region is a common strategy to give yourself the sustain required to overcome the increasingly difficult enemies. Altogether, he offers 6 defensive boons that either reduce damage taken or give you Armor.
Grabbing
Trusty Shield early on in a run is a smart move to keep your health high throughout a Night. Regardless of your primary God or Weapon Aspect, every build will benefit from having the increased tankiness
Hephaestus enables.
If you manage to get a high rarity on
Volcanic Strike or
Volcanic Flourish then multiple poms to decrease Blast Recharge Time, the "ding! ding! ding!" deals massive damage. For the luckiest, top the Volcanic build off with either
Seismic Servo or
Chain Reaction, and you'll have a very fun burst damage build going into the final boss.
Jeweled Pom and
Calling Card have also made
Hephaestus blast builds more consistent and viable.
Aphrodite
When you want to go for big, hard hits,
Aphrodite is your best choice. While her attack and specials don't inflict a Curse, a Heroic Flutter Flourish ramps up your Aspects damage to +250%! Any Aspect with high damage close-range attacks synergizes well with
Aphrodite's boons.
Weak is a decent defensive Curse since Weak-inflicted enemies deal 30% reduced damage. Because it offers no offensive value, however, it's considered one of the weaker status effects in Hades II. Weak also only lasts a single second, so outside of
Glamour Gain, you can't rely on the damage reduction.
Her CC from
Rapture Ring is great for keeping your distance from dangerous enemies significantly easier. Her non-core boons are ok, but not worth taking
Aphrodite for if you don't need Weak or her Attack/Special.
Another area where
Aphrodite's beauty reflects is in her Duo Boons. Her Duos with
Zeus and
Hestia are must-haves. They make your build so much stronger that it's often worth using two God Keepsakes to guarantee you fulfill the Offering Requirements.
If you can get a bit lucky, being able to potentially inflict every curse in the game with her Legendary,
Nervous Wreck, is ridiculously strong.
Hestia
Scorch deals damage over time and can be stacked when inflicted multiple times in a row. To maximize damage per second with Scorch, you'll want to put
Hestia on a fast-hitting Aspect move. Examples include
Aspect of Hel Attack,
Aspect of Anubis Attack, and
Ygnium Special.
The problem with
Hestia builds is that you need a high rarity or Pom level on the core move, plus
Pyro Technique, and ideally
Burning Desire. You won't always be so lucky, or it may not be until late into the run that you get all the necessary boons, which makes the earlier regions more difficult.
If you're not going for a full-on Scorch build, it's better to choose one of the S-tier or A-tier Gods when given the choice.
Hestia's synergy with most builds is limited by a lack of useful non-core boons and a niche Magick boon.
Demeter
Being able to freeze any standard enemy and slow bosses is immensely helpful. Many enemies can be destroyed by burst damage while they are frozen, so they'll never have the opportunity to hurt you. Freeze also makes Omega-centered builds easier because it buys you time to safely channel your Omega moves.
While her Rush and Gain aren't that great, they come in handy when you have no other options. Plus,
Tropical Cyclone makes her Rush deal high damage.
For her non-core boons,
Weed Killer is fantastic for Omega Attack builds, and the cost of an extra 10 Magick is well worth the increased damage.
Frosty Veneer is difficult to activate because of the high elemental requirement, only triggers on high damage hits, and is not necessarily worth going out of your way to try to acquire water element boons. Her Duos are very build-dependent and are not always better than taking standard Boons that may be more useful to your build.
Through Freeze, healing, and damage mitigation,
Demeter offers a more defensive playstyle that works equally well as a primary or secondary God.