Example Full Arcana Unlock Path
Starting Unlocks (High Priority)
The Sorceress (I) →
The Wayward Son (II) →
Persistence (VII) →
Death (XII) →
The Swift Runner (XI) →
The Furies (VI)
Survival is extremely difficult in Hades 2, and these are the first Cards you should be unlocking and activating for every run.
Secondary Path
↳
The Huntress (III) →
The Messenger (VIII) →
Eternity (IV) →
The Moon (V) →
Night (X) →
The Boatman (XVII) →
The Centaur (XIII) →
Origination (XIV)
After you've finished the secondary path, focus resources on upgrading the cards you already have. Then, when convenient, continue unlocking the Cards in the remaining paths below.
Your Choice
↳
The Champions (XXII) →
The Lovers (XV) →
The Artificer (XVIII) →
The Enchantress (XVI) →
The Fates (XXI)
Next on the agenda should be upgrading the bottom left corner cards to maximize rerolls. Boon rerolls are a potent tool for consistently getting strong builds in Hades 2.
Save for Last
↳
The Queen (XX) →
Strength (XXIII) →
Divinity (XXIV) →
Excellence (XIX) →
Judgement (XXV) →
The Unseen (IX)
These Cards will either not be used as often as the rest and must be fully upgraded before they become useful. Only upgrade these when you've already maxed out the rest of your deck.
Best Early Game Arcana Build

Here is one example of a good Arcana build that uses only 10 Grasp. These are quick to unlock, and all have a high impact on your run, without costing too much Grasp.
Although most would use 2 Grasp on
Persistence (VII), if you find, "the best defense is a good offense," to be true, mix it up! Killing an enemy 30% faster from standard Attack/Special leaves them alive for less time. Consequently, you won't have to dodge for as long because it will take fewer strikes to vanquish the foe.
Don't feel that you have to use just one build. Play around with different loadouts every night as you unlock more Cards and Grasp!