Orphie Lighter Nicole

There's some variant on her build:
Full ER: 2pc Swing Jazz + ER Disc 6
Hybrid: 2pc Hormone Punk + ER Disc 6 or 2pc Swing Jazz + ATK Disc 6
full ATK: 2pc Hormone Punk + ATK Disc 6
All of them is valid (but if you don't have her signature, you should go full ER) and depends heavily on your drive disc choices (not many have ER Disc 6 with high crit substats roll).

2pc Branch & Blade Song is also a good option.

Note that it's easy to overcrit on Orphie with Nicole
(CR: 25% core + 20% sig + 12% Sha Harm + 15% Nicole)

As Lighter is buffed by both Orphie and Nicole (although not all the time), building him on damage (still with impact disc 6) is the best option, and using his ultimate inside the stun for damage burst is also good, since he doesnt need his ultimate to stun, as long as he got a lot of dodge counter (except for the last stun window).

Puffer Electro 2pc a small effort to make a dent on Hunter high DEF, but realistically Lighter damage here is still negligable than Orphie.

Kaboom the Cannon for more ATK buff for Orphie, better than The Vault as the DMG% buffing on the team is already saturated.

Nicole not only provide more buffing on Orphie damage output (95% DEF shred goes crazy), but also generate decibels for the team (high energy generation = high energy usage = high decibels generation) and recharge Orphie energy by her ultimate, giving Orphie more EX aftershock to deal more damage. by my testing, Nicole is better than M0W1 Trigger in this matchup.