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PoE 2 Build

0.4 Poisonburst Pathfinder Leveling Guide

Updated on Dec 14, 2025
Dec 14, 2025

Build Overview

This is my leveling guide for Poisonburst Pathfinder, swap to the endgame guide after campaign.

You'll be leveling as poison from the very start with this build guide.

Vendor regex: "y: \+|ts: S|\d+% i.+mov|ward|phy.*att.*|uiv"
(You copy and paste this into your vendor window, to easily see items you might want to buy)

Build Variants

Equipment

item
1
item
4
item
3
item
7
item
6
item
4
item
2
item
8
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item
10
item
Equipment Priority
+10

Check the vendor in town every 1-2 lvls for flat damage gloves, every flat for the build is massive for dps.

You always want the highest physical damage bow you can find, nothing else really matters on the bow because you don't scale elemental damage. Artillery Bow at lvl 46 is a big power increase if you get one with %phys (pretty common to find from a vendor or gamble). Zealot Bow at lvl 39 is another solid base and Cultist Bow is pretty decent after the buff.

Movement speed on boots is also extremely good if you can find them, try to search the vendor every 1-2 lvls. I would never swap out movement speed boots, only replace them with other boots that have movement speed.

Besides that you're just looking for life/resist on gear, but flat damage is the most important on gloves/rings.

!!!!Important!!!!!
Always salvage weapons with quality for whetstones and always salvage items with sockets for artificers orb, this is extremely important for gear upgrades throughout the campaign.

I also personally prefer to vendor all rares for gold to gamble in act 2 and act 3 for better gear.

Skill Gems

Support Gem Requirements:

Str 25

Dex 30

Int 15

1

Poisonburst Arrow

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2

Vine Arrow

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3

Toxic Growth

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4

Gas Arrow

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5

Withering Presence

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6

Herald of Plague

Gem Priority
+14

Quality prio: Toxic Growth > Poisonburst Arrow > Vine Arrow > Gas Arrow
Link prio: Toxic Growth > Poisonburst Arrow > Vine Arrow > Gas Arrow

Poisonburst Arrow is your main clear for the whole campaign, will often combo it with Toxic Growth to clear packs of enemies.

Toxic Growth/Vine Arrow is used for bosses or rare monsters.

Gas Arrow will auto proc your Toxic Growth.

Boss rotation: Use Vine Arrow into Gas Arrow and spam Toxic Growth, re-use gas arrow whenever the duration runs out.

Important: Before you acquire Persistent Ground II you have to avoid flat fire damage on gear or you'll ignite bosses which will instantly pop of your Gas Arrow clouds, this is only a very short time in the lvling period but it's pretty important to avoid this.

You'll swap between Withering Presence and Herald of Plague(if you're lazy just keep herald of plague on) - Withering presence is just for some extra boss damage as herald of plague doesn't add any dmg for bosses.

Passive Tree

main:
123
123
set 1:
20
20
set 2:
20
20

In general just use dexterity for your small attribute nodes. Use strength/int if you need it for gear or support gems.

Ascendancy order:
Overwhelming Toxicity > Path Seeker > Running Assault

Quest Rewards

Check which quests you’ve completed on your character
Clearfell — Beira of the Rotten Pack
Not Specified1 choice
Hunting Grounds — The Crowbell
Not Specified1 choice
Freythorn — The King in the Mists
Not Specified1 choice
Ogham Farmlands — Una's Hut
Not Specified1 choice
Ogham Manor — Candlemass, the Living Rite
Not Specified1 choice
Keth — Kabala, Constrictor Queen
Not Specified1 choice
Valley of the Titans — Medallion
Not Specified2 choices
Deshar — Final Letter
Not Specified1 choice
The Spires of Deshar — Sisters of Garukhan
Not Specified1 choice
Jungle Ruins — Mighty Silverfist
Not Specified1 choice
The Venom Crypts — Venom Draught
Not Specified3 choices
Jiquani's Machinarium — Blackjaw, the Remnant
Not Specified1 choice
The Azak Bog — Ignagduk, the Bog Witch
Not Specified1 choice
The Molten Vault — The Molten Vault
Not Specified1 choice
Aggorat — Blood Sacrifice
Not Specified1 choice
Journey's End — Captain Hartlin
Not Specified1 choice
Eye of Hinekora — Navali's Rest
Not Specified1 choice
Halls of the Dead — Yama The White
Not Specified1 choice
Halls of the Dead — Tawhoa's Test
Not Specified2 choices
Abandoned Prison — Goddess of Justice
Not Specified2 choices
Halls of the Dead — Tasalio's Test
Not Specified2 choices
Halls of the Dead — Ngamahu's Test
Not Specified2 choices
Wolvenhold — Oswin, the Dread Warden
Not Specified1 choice
The Khari Crossing — Akthi and Anundr
Not Specified1 choice
The Khari Crossing — Molten Shrine
Not Specified1 choice
Qimah — Tabana's Pillar
Not Specified7 choices
Kriar Village — Lythara, the Wayward Spear
Not Specified1 choice
Howling Caves — The Abominable Yeti
Not Specified1 choice

How it Plays

Quest Rewards in Campaign

  • 1) Medallion: Increase charm charges gained
  • 2) Venom reward - Stun threshold
  • 3) Tattoo act 4 reward - Dex/Int/Fire resist(can also take str)
  • 4) Prison - life recovery from flask
  • 5) Interlude - Can choose Resist, MS or global defense (it's free to change at anytime)

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