Hammers
The best Hammers are
Hidden Helix and either Enduring Coil or
Clean Coil. The extra Special Flame from Hidden Helix is OP and will greatly increase your damage output. You don't need to do anything different, just enjoy the extra damage.
Endruing Coil makes your Omega Specials last longer. You'll use less Magick overall, have more time to spam Omega Attacks, and don't have to stop to channel Omega Specials as often.
Clean Coil is another good choice, as it increases your Channel Speed. You can position a bit more aggresively near the enemies since you'll be able to activate and dodge quicker.
Hermes
From
Hermes, the most useful boons will increase Omega Move channel speed so you can activate Night more often.
Winner's Circle will add Omega Casts into the Mix as another incredible source of AoE damage. Once you have this Boon, you should alternate between Special and Cast Omegas, then only use Attack when neither of these are available.
Whenever you get Winners Circle, look for
Local Climate from Demeter to increase Omega Cast damage.
Magick and Health Requirements
Because we started with Hecuba and are taking a high Magick Gain, you can take a balanced choice of Hearts and Magick. If you find yourself running out of Magick from priming, then you know you need Magick.
When you do find yourself without Magick, standard Specials will be your go-to. Only use Attack if you need to keep your distance.
Hexes
Thanks to our high Magick use, we'll be activating our Hex frequently. Unleash an Omega Special, then activate
Dark Side. Your Omega Specials will persist and keep damaging the enemy while you're invincible and using the alternate moveset.
Start with a Special, Omega Cast, then hold Attack until you can Special again. By then Darkside will be over and you need to start dodging again.
If you did get Aphrodite during the run, you'll be able to Path to her Godsent Allure of Aphrodite. Stay right on top of your target when using the Godsent to hit them with every Heartthrob.
NPC
Shadow Pounce enables critical damage after Dashing for Omega Special, Attack, and Cast. The crit chance stacks with
Aspect of Melinoë and
Night (X) so you'll have 3 different methods of dealing Critical damage on your Omegas!
Thanks to the rapid hit of Omega Specials,
Support Fire would also be a great
Artemis Boon to have. Especially in standard encounters, the auto-firing arrows help deal with groups of enemies.