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Borderlands 4 Guide

How to Unlock The Legendary Infection Jakobs Pistol

Weapons
Legendary Loot
By Lewis0n
Updated on Sep 11, 2026
Sep 11, 2026

Overview

Infection is a Jakobs Pistol

Its special effect is Infection - Critical Hits have a 30% Change to change Element to Radiation with increased Radiation Status Effect Chance and increased Radiation Status Effect Damage for 6 seconds.

How To Unlock

Unlock Location:

  • Progress through the (FL4k And The Last Resort) DLC until reaching the Boss
    Lieutenant Harmony

Farm Method:

  • Defeat Lieutenant Harmony to get a chance at the Infection.
  • After use the Encore Machine nearby to reset the fight.
  • Repeatedly defeat Lieutenant Harmony until the Infection drops.

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Table of Contents

1. Overview2. How To Unlock3. Comments

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