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PoE Build

Nightblade Mamba

3.28 Mirage
presentationShadow
presentationAssassin
End Game
Verified
Updated on Mar 15, 2026
Mar 15, 2026

Path of Building Code

Build Overview

This build uses Bino's Kitchen Knife and The Hateful Accuser to leverage spreading poison damage scaled by Low Tolerance and Viper Strike of the Mamba.

It clears off-screen, melts uber bosses, and can run every map modifier in the game for "Risk Scarab" farming.

For league starting in trade league, I would recommend playing my Poisonous Concoction Build until you have acquired enough wealth to buy:

- Bino's Kitchen Knife

- Essentia Sanguis

- AT LEAST 3x Low Tolerance jewels

- Voices (Adds 5 Small Passive Skills)

Please do not play my builds if you are a newer player.

Strengths and Weaknesses

  • insane clear (like 2 screens away)
  • good single target
  • fast
  • semi-complicated
  • not ssf-friendly

Build Variants

Equipment

Bino's Kitchen Knife
The Hateful Accuser
Warlock Gloves
Lich's Circlet
Necrotic Armour
Mageblood
Whispers of Infinity
Shavronne's Revelation
Essentia Sanguis
Phantom Boots
Topaz Flask
Bismuth Flask
Quicksilver Flask
Quartz Flask
Wine of the Prophet
Brood Cut
Damnation Shine
Dragon Spark
Honour Wound
Maelstrom Ornament
Plague Desire
Brutal Restraint [2394; 2; Wind Dancer]
Forbidden Flame
Forbidden Flesh
Melding of the Flesh
The Light of Meaning
Voices
Voices
Watcher's Eye
New Item
New Item
New Item

Passive Tree

main:
123
123
ascendancy:
8
8
Keystones
Ghost Dance
Cannot Recover Energy Shield to above Evasion Rating Every 2 seconds, gain a Ghost Shroud, up to a maximum of 3 When Hit, lose a Ghost Shroud to Recover Energy Shield equal to 3% of your Evasion Rating
Chaos Inoculation
Maximum Life becomes 1, Immune to Chaos Damage
Perfect Agony
Damage over Time Multiplier for Ailments is equal to Critical Strike Multiplier Critical Strikes do not deal extra Damage Non-Critical Strikes cannot inflict Ailments
Masteries
Evasion and Energy Shield Mastery (2)
30% increased Evasion Rating while you have Energy Shield
20% increased Energy Shield Recovery Rate if you haven't been Hit Recently
Accuracy Mastery (2)
Gain Accuracy Rating equal to your Intelligence
40% more Accuracy Rating against Unique Enemies
Mana Mastery (1)
12% increased Mana Reservation Efficiency of Skills
Claw Mastery (1)
Skills Supported by Nightblade have 40% increased Effect of Elusive
Energy Shield Mastery (1)
100% increased Energy Shield from Equipped Helmet
Spell Suppression Mastery (1)
Prevent +3% of Suppressed Spell Damage
Critical Mastery (1)
+25% to Critical Strike Multiplier against Unique Enemies
Leech Mastery (1)
100% increased total Recovery per second from Life, Mana, or Energy Shield Leech
Poison Mastery (1)
Poisons you inflict deal Damage 20% faster

Skills

New Item
Necrotic Armour
Viper Strike of the Mamba
Greater Ancestral Call
Melee Physical Damage
Nightblade
Void Manipulation
Swift Affliction
Damage on Full Life
Ruthless
Cruelty
New Item
Phantom Boots
General's Cry
Autoexertion
Cyclone
Withering Touch
Brutality
New Item
Lich's Circlet
Enlighten
Flesh and Stone
Discipline
Purity of Elements
New Item
Warlock Gloves
Whirling Blades
Brutality
Faster Attacks
Frostblink
Bino's Kitchen Knife
Slaughter Knife
Despair
Desecrate
Precision
Essentia Sanguis
Vaal Claw
Clarity

How it Plays

To clear maps, just 1-button Viper Strike of the Mamba.

For bossing, cast Penance Mark followed by Despair.

Then, cast Desecrate twice on top of the boss to allow for your General's Cry to automatically apply wither.

From there on out, just spam Viper Strike of the Mamba and recast Desecrate if the boss moves.

How it Works

There are many complicated interactions in this build. Please refer to the build video.

Video Guide

Stats

Stats are displayed for the "Mageblood Melding" Variant only
Character
Attributes
121 / 
237 / 
309
Movement Speed
280%
Pantheon Major
Lunaris
Pantheon Minor
Gruthkul
Charges
Endurance Charges
3
Frenzy Charges
3
Power Charges
3
Defensive
Life
1
Energy Shield
9,964
Mana
2,964
Armour
0
Evasion Rating
16,620
Block
20%
Resistances
90% / 
90% / 
90% / 
-8%
Simulated
Effective Health Pool
142K
Max Hit
21K / 
121K / 
121K / 
121K / 
Skill DPS Estimation
Viper Strike of the Mamba
11M

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