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PoE Build

Perfect Agony Poisonous Concoction Assassin

3.28 Mirage
presentationShadow
presentationAssassin
Verified
Starter
End Game
Featured
Updated on Mar 10, 2026
Mar 10, 2026

Path of Building Code

Build Overview

This build is designed for the first 40-60 hours of gameplay. While the skill can have some very good endgame scaling, Assassin is not the best choice at high investment.

Some preventative troubleshooting tips:

  • do not equip a weapon (disable auto-equip weapon in your settings)
  • roll life flasks for "Increased Amount Recovered"
  • ensure flasks are upgrade (Saturated Divine Life Flask is Best)
  • if suffering with mana, take Charisma on the passive skill tree

Strengths and Weaknesses

  • easy to gear
  • high single target
  • fast campaign
  • easy-to-follow (get checked for brain worms if you are struggling)
  • below average clear
  • bad defenses
  • delayed damage
  • transfigured gem

Build Variants

Equipment

Sharktooth Claw
Goathide Buckler

Passive Tree

main:
123
123
ascendancy:
8
8

Skills

Cobra Lash
Chance to Poison
Volley
Momentum
Sniper's Mark
Frostblink
Precision
Shield Charge
Faster Attacks
Withering Step

How it Plays

Throw Poisonous Concoction of Bouncing to deal damage. When Plague Bearer is fully incubated, press the button to create a damaging chaos aura around your character to supplement clearing problems.

Shield Charge is your primary movement skill. Use it while also holding down the move button to have smooth mobility. If you find yourself charging into terrain too often, I would suggest walking more. Even many top racers often overuse Shield Charge. You can also animation cancel the end of it with Frostblink if you are a real gamer!

For bosses, press Desecrate twice on top of the boss, allowing General's Cry clones to automatically appear (no longer needed when you reach 20% gem quality on Poisonous Concoction of Bouncing).

In the final setup provided, manually cast Despair and Punishment for single target encounters. Alternatively, you can use a glove implicit for Despair.

How it Works

Throw flask, flask poison, poison kill.

Video Guide

Stats

Stats are displayed for the "Early Trade" Variant only
Character
Attributes
74 / 
281 / 
213
Movement Speed
172%
Bandits
Alira
Pantheon Major
TheBrineKing
Pantheon Minor
Ryslatha
Charges
Endurance Charges
3
Frenzy Charges
3
Power Charges
4
Defensive
Life
4,207
Energy Shield
1,845
Mana
832
Armour
0
Evasion Rating
10,566
Block
24%
Resistances
76% / 
76% / 
76% / 
76%
Simulated
Effective Health Pool
44K
Max Hit
11K / 
35K / 
35K / 
35K / 
28K
Skill DPS Estimation
Poisonous Concoction of Bouncing
40M

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