Check the other tabs for separate PoB Links
This Endgame Setup combines the Mapping and Bossing Setup using Weapon Swap. However, there are still differences in Equipment and Gem Links.
How the Build Works
The clear portion of the build works like many other 
Lightning Spear builds. 
Tangletongue allows you to deal massive Crit Damage with the "Fork Critical Hits" line. In exchange, the weapon itself doesn't have much damage.
To solve this, the build uses Rings with high Flat Damage, scaled further with 
Ingenuity. Flat damage on gloves is also a good bonus.
One Shot Bosses
Rake and 
Blood Hunt are used to 2 shot bosses. Since the build deals elemental damage (from the flat damage on Rings), we use 
Blood Barbs to have it contribute to Bleeding Magnitude.
Enfeeble + Blood Barbs makes the Bleed Aggravate, dealing more damage even if the boss isn't moving.
Concoct and Ambrosia are two new Support Gems that consume Flask Charges to buff up Rake. Since the build looks to one-shot bosses, you don't need to sustain these charges. With well rolled Flasks, these Supports will grant 75% More Bleeding Magnitude and 75% Damage as extra Lightning Damage respectively.
Disengage is linked with Supports to apply a large Shock for more damage. 
Orb of Storms with Font of Rage will allow you to setup 30 Rage.
Lastly, we have 
Infernal Cry, which grants an additional 140% damage as extra Fire Damage when used near a Unique enemy. (at 20% Quality)
Crown of Eyes (Bossing Setup) allows Spell Damage modifiers to affect Attacks.
All of this Elemental Damage, Crit, and more contribute to a massive Bleed which you can use to one/two-shot just about any boss with Rake and Blood Hunt.
Campaign Buffs
- Act 2 Relics: +30% increased Charm Charges Gained
- Act 5 Relics: +30% increased Charm Charges Gained
- Act 3 Venom: Stun Threshold
- Act 6 Venom: Chaos Resistance
Witch
Blood Mage
Gore Spike (Ascendancy Passives).
