Kai'Sa·Runes for Bot

Kai’Sa benefits from mixed damaging items. Buying items that will provide AD, AP and attack speed will give you a variety of evolved skills.

Kai'Sa's Ultimate R is a long-range dash that gives her a big shield. Try to reposition yourself with it in a team fight so you can survive long enough to deal a lot of damage.

Try and use your Q on the enemy when they’re isolated and not near minions. This will force your Q to focus just the enemy champion which will, in turn, mean they take more damage and be easier to kill.