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Diablo 4 Build

Poison Twisting Blades

presentationRogue
Season 8
Updated on May 22, 2025
May 22, 2025

Build Overview

This build revolves entirely around using Twisting Blades to apply Poison Imbuement, utilizing Alchemical Admixture Key Passive for scaling.

It can do devastating amounts of damage while being incredibly tanky. If you miss the good ol' Poison Twisting Blades from S1-S2 this is the build for you.

Strengths and Weaknesses

  • Great Single Target DPS
  • Great AoE DPS
  • Very Tanky
  • Scales Very Hard with Paragon and Glyph Level
  • Small AoE

Build Variants

This is your starter variant.

Assigned Skills

Primary
5
5
Secondary
1
1
5
1
Specialization

Aspect & Uniques

HelmUndying Aspect
Chest armorUmbrous Aspect
GlovesAspect of Contamination
PantsEnshrouding Aspect
BootsSlice and Dice Aspect
AmuletAspect of Corruption
Ring 1Aspect of Creeping Death
Ring 2Starlight Aspect
Dual wield weapon 1Vehement Brawler's Aspect
Dual wield weapon 2Aspect of Elements
Ranged weaponBladedancer's Aspect

Starlight Aspect and Poc + Lum are used to help solve Energy problems before we get Starless Skies.

Try to cap our Armor and Resistances.

Skill Tree

Available0 (0)
Spent59 (12)

We use Subo to increase our Poison Imbuement damage with Scorched Earth and to reveal enemies and resources with.

Paragon Board

Points Spent0

No Glyphs Installed

Stats

  • Str:99
  • Int:99
  • Dex:99
  • Will:99
  • Mercenary

    How it Plays

    1. Cast Shadow Step for Mobility and to break CC.
    2. Cast Dash for Mobility.
    3. Cast Rain of Arrows on Cooldown to apply Poison Imbuement, Mixed Shadow Imbuement and enable all three Eldritch Bounty buffs.
    4. Cast Caltrops/Smoke Grenade for Damage.
    5. Cast Dark Shroud to keep it up if the Variant is using it.
    6. Cast Poison Imbuement.
    7. Spam Twisting Blades.

    Remember to use your Health Potion periodically to enable Unstable Elixirs.

    How it Works

    This build is enabled by Alchemical Admixture greatly scaling our Poison Imbuement damage.

    Twisting Blades is the perfect vehicle for Poison Imbuement because it has a massive amount of Base Damage when combined with Bladedancer.

    Rain of Arrows is used with Hakkan's Grasp because it gives us 16 Ranks to our Imbuement Skills and also makes Rain of Arrows cast Shadow Imbuement and Cold Imbuement. This increases our damage via Eldritch Bounty, which increases our Shadow/Cold Tooltip Damage and that ends up feeding into Alchemical Admixture.

    Leveling

    You can find the Dance of Knives leveling guide HERE. That is by far the strongest way to level.

    Mercenaries

    We use Subo with Molotov and Snipe for more Damage over Time.

    Varyana is used with Earthbreaker to Knockdown and increase the damage Malice provides us.

    Boss Powers

    We use Beast in the Ice's Sleet to help us Freeze for Frigid Finesse and Control.

    The rest of the powers are the strongest damage multipliers we have available. Sinerat's Flames is exceptionally good because we double dip Non-Phys Damage.

    Runes

    We use Tam, which is our best source of Offering, combined with Vex to buff all our Skill Ranks by 3. This is especially good in this build because we benefit from ranks to Shadow Clone, Twisting Blades and Poison Imbuement.

    Our second set of Runes is Igni, our second best source of Offering, combined with Mot to provide us with free Dark Shroud without wasting an Aspect or a Skill Bar slot.

    Early on when we are struggling to keep our Energy up we will use Poc with Lum to generate Energy as we spend it.

    Elixirs and Incenses

    It's important to run Elixirs and Incenses at all times. Not only because they increase our XP gain but also because they provide very strong combat boosts.

    We use Elixir of Advantage to provide us with more Attack Speed.

    We use Dexterity, Armor (if not capped) or Maximum Life and All Resistances.

    Attack Speed Breakpoints

    Because the game's server operates in frames (images), Skills can only be cast in a whole number of frames. This means, for example, that you can't cast a Skill in 10.2 frames. To extend this example further, that means that all Attack Speed values that lead to a cast time of 10.01 to 10.99 frames would mean you end up casting at 11 frames, effectively wasting all Attack Speed gains from 11 frames to 10.01.

    In order to avoid wasting Attack Speed, you can calculate the Attack Speed Breakpoints for your skills using THIS SHEET.

    You might be wondering how frames translate into actual Cast Speed. Because the server runs at 60 frames per second the way we translate frames into Cast Speed is with the formula: 60 / Frames = Casts per Second.

    In this particular build we aim for the 11 Frame (138.3% Attack Speed) Breakpoint.

    Alchemical Admixture Explained

    Alchemical Admixture requires us to attack with 3 different elements to get activated, we achieve this by making Rain of Arrows cast Poison, Shadow and Cold Imbuement.

    This makes our Poison Imbuement do [x]40% more damage. This multiplier also scales with 20% of our total amount of Damage with Poison, Cold and Shadow. This last part has some hidden implications:

    • [+]Non-Physical Damage counts for triple the amount for Alchemical Admixture.
    • [x]Non-Physical Damage and [x]Poison Damage double dip by buffing our Poison Damage and also our Tooltip Values.

    Masterworking and Greater Affixes Explained

    Masterworking

    Masterworking (MW) enhances an item's stats. Each MW rank boosts all affixes by 5%. Ranks 4,8,12 give a 25% bonus to a random affix (MW Crit).

    In this planner, the color blue on an item denotes that the affix got one MW Crit, the color yellow denotes that the item got two MW crits and the color orange denotes that the item got three MW crits.

    For future reference the amount of MW Crits on an affix will be denoted by 1MW, 2MW, 3MW.

    Greater Affixes

    Greater Affixes (GA) on an item force the affix to roll at the top of it's range of possible values and then applies a 50% increase to its value. GA increases are additive with Masterworking increases.

    In this planner, the yellow star to the left of an affix denotes that is a GA.

    Example

    To put it all in to practice, let's calculate what stat increase a GA Affix on a 12/12 Masterworked item with 2 MW Crits gets:

    Ranks 1-3, 5-7, 9-11 all give 5% -> 9 * 5% = 45%

    Two MW Crits -> 2 * 25% = 50%

    GA = 50%

    Total = 45% + 50% + 50% = 145%

    Masterworking and Greater Affix Priority

    Unless a certain amount of a stat is required and no more, like in the case of Attack Speed Breakpoints, Armor and Resistances, GA and MW priority should be easy to follow.

    Guides, which follow a Starter -> Midgame -> Endgame progression, are structured such that the difficulty of the MWing outcome and amount of GAs on items also progresses as expected.

    For example, a Starter variant will generally have 1GA items with three 1MW affixes. A Midgame variant will generally have 2GA items with a 2MW Affix and a 1MW affix. An Endgame variant will generally have 2GA/3GA items with a 3MW affix.

    From this you can derive that the GA on the starter version is the most important, the second GA added is the second most important and the third GA added is the third most important affix.

    In the case of Masterworking, 3MW = most important affix, the 1MW in the Midgame variant is the second most important affix and from the Starter variant with three 1 MW affixes you can know which is the third most important affix.

    When GA and MW don't align you are most likely in the presence of a stat with a certain threshold you have to meet or a cap and those will be explicitly stated in the guide anyways.

    In the case of Uniques GA and MW, progression standards are generally shifted by one as they are easier to MW because they have 4 affixes and also easier to acquire with multiple GAs.

    Frequently Asked Questions

    Changelog

    04/27/2025

    • S8 Update

    01/23/2025

    • Changed Clone to RoA since CLone is bugged.

    01/19/2025

    • S7 Update

    10/03/2024

    • S6 Update

    08/06/2024

    • S5 Update

    05/09/2024

    • S4 tentative changes

    11/03/2023

    • Added Shako
    • Added Tibault + Condemn
    • Removed Penitent Greaves
    • Removed Umbrous
    • Changed stat priority on boots and amulet
    • Removed Frigid Finesse and Dark Shroud -> Siphoning Strikes + Exploit
    • Have made the Paragon Board way more defensive to account for having to use Tibault's Will

    10/30/2023

    • Added Asheara's back after Attack Speed testing

    10/23/2023

    • Changed skill tree slightly to account for Andariel's Visage.

    10/21/2023

    • Considerably changed the Paragon Board because Core/Cutthroat were stealth nerfed.
    • Gearing was also changed for that reason.
    • Decided to drop Poison Trap despite the synergy with X'Fal because it just didn't feel that great to use.

    10/20/2023

    • Edited written sections to account for changes to the build
    • Added Cowl back to the helm slot
    • Added X´Fal, very strong because it scales
    • Removed Asheara because we already hit attack speed cap
    • Paragon Board change to account for wrong Res calculations (forgot to halve int resistance) and for X'fal inclusion.
    • Skill Tree change to account for Poison Trap inclusion.

    10/19/2023

    • Changed Paragon Board
    • Removed Metamorphosis for Accursed Touch
    • Removed Tibault's (stats too bad)
    • Added Penitent Greaves and Noxious Ice
    • Added item swaps to Bossing section

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