Quest boards have a wide range of opening lines depending on the Relic you are hoping to play. At the start, they usually lean into another item as their carry, at least until the point where the first Quest has been fulfilled. Common openers include
Candles,
Nightshade /
Dragon's Breath,
Refractor, and
Aludel.
Candles — A great Burn opener to lead into
Eternal Torch. Prioritize the fastest Small non-Ammo items to maximize its Charge capabilities.
Nightshade /
Dragon's Breath — Can play into
Idol of Decay or
Life Conduit. It's good enough with just 2-3 Regen items, and has highroll potential.
Refractor — This scales very well alongside
Sands of Time +
Smelling Salts. Lifesteal is highly recommended, so look for
Mortar & Pestle early on.
Aludel — Not ideal, but a passable flex opener. With a bit of Poison scaling (ex.
Emerald,
Fungal Spores) it can get the job done in the first few days.
While it's possible to purchase more than one primary Quest Relic at a time, in order to maintain a stable economy, we recommend choosing only one to commit to.
Catalyst Spawners
Aludel — A zero commitment starting point, since it can double as both a
Catalyst spawner and playable threat.
Mortar & Pestle — The obvious choice if you're playing a
Refractor line. This generally preserves Stash space the longest.
Cellar /
Potion Potion — Will rarely have additional benefits, but they're spawners if you need them.
It's always helpful to have at least one of these early on, as a lucky Transform can provide a major power spike. Mak greatly benefits from playing opportunistically.
Additional Notes
Blank Slate — Playable alongside any of the primary Quest Relics. During PvE fights, consider (safely) weakening your board to allow time for more casts.