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STS 2 Tier List

Slay the Spire 2 Potions Tier List

Updated on Mar 11, 2026
Mar 11, 2026

Overview

Welcome to our preliminary Potions tier list for Slay the Spire 2. Here we'll give you our rankings of all Potions available in the game.

Seeing as the game has just launched into Early Access, consider this an early look while we still learn and explore the mechanics of the game. We'll be updating the list along the way, especially as new patches shake things up.

Methodology

Potions are the ultimate life savers in Slay the Spire 2. A one time burst of power can be the difference between survival and getting sucked into the maw of an Insatiable sand worm. Here's how we're ranking them:

Please note this list will not include event potions. All Potions are listed in alphabetical order in their Tiers.

Ranking

S-Tier: The best of the best. These Potions are highly sought after regardless of the situation you're in, and are worth holding on to for boss fights.

A-Tier: Potions in this tier are very powerful, but not quite as broken as those in S tier.

B-Tier: Very solid options but are either not as good, more niche or have a chance to whiff

C-Tier: Your standard helpful Potion that you'll be happy to see but probably stay on the Shopkeeper's rug.

D-Tier: Better than nothing but make you wish you had something else.

Tier List Maker

S
A
B
C
D