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PoE Build

MrRonit's Poisonous Concoction Zero to Hero

3.27 KotF
Creator
Starter
Speed Leveling
End Game
presentationRanger
presentationPathfinder
Updated on Nov 14, 2025
Nov 14, 2025

Path of Building Code

Build Overview

[3.27] Welcome to MrRonit's Poisonous Concoction Starter build that is SUPER beginner-friendly as it is not gear dependant.

We initially start with Caustic Arrow till level 12 and then move to Poisonous Concoction as our main skill whilst doing the campaign! This can take you through to even early mapping. Eventually we want to get Poisonous Concoction of Bouncing which is an even better version which has even more damage than the original skill!

The damage for this setup comes from your skill gem and your life flask and that's basically it making it very easy to level with and start mapping with! We do not need a weapon at all! Making it super cheap to gear!

This build is a Leaguestarter and you will want to use this for levelling, early mapping and will easily get you 2 voidstones and to T16/16.5 maps. It also does really well as you scale it up with more investment for 4 voidstones and T17 maps

In patch 3.27 we now have grafts - powerful additions that grant you an additional skill into your build. I'll outline below which ones to aim for!

Strengths and Weaknesses

  • Minimal Gear Requirements Up To 2 Voidstones
  • Fast Levelling
  • Strong Defences
  • Will need decent investment for 4 voidstones and T17s

Build Variants

The build that will allow you to conquer the voidstones, T16-17 maps! We incorporate 2x Betrayal's Sting to improve DPS further and make up the lost resistances through Viridian Jewels. We also get Large Cluster Jewel and x2 Medium Cluster Jewel to get notables such as Follow-Through and Spiked Concoction which will help with endgame pushing.

Equipment

Betrayal's Sting
Asenath's Gentle Touch
Silken Hood
Syndicate's Garb
Leather Belt
Fury Valve
Betrayal's Sting
Leper's Alms
Velour Boots
Battering Uulgraft
Molten Xophgraft
Divine Life Flask
Replica Sorrow of the Divine
Quicksilver Flask
Jade Flask
Silver Flask
Chimeric Cut
Chimeric Joy
Eagle Wound
Maelstrom Ruin
Maelstrom Ruin
Maelstrom Ruin
Maelstrom Ruin
Maelstrom Ruin

Important Uniques

Leper's Alms is a great budget shield option that provides great damage and also some spell suppression which is useful

Replica Sorrow of the Divine gives you Eldritch Battery which solves mana issues - make sure to enchant it with Used When Charges Are Full enchant so it is automatically cast otherwise you will keep needing to cast it to attack

Fury Valve gives you more projectiles on your Poisonous Concoction of Bouncing and some elemental resistance. Anoint for Toxic Strikes

Asenath's Gentle Touch adds both Temporal Chains and gives an AoE explosion after every kill meaning you can deal with 3.27 Breach mechanic really easily!

Betrayal's Sting gives us even more DPS through adding another poison - in the endgame we get TWO of these rings! We use Viridian Jewels with +all elemental resistances to make up for it!

Other items

Look for helmet, boots, ring, belt with high resistances/life/movement speed

Grafts

The two best grafts to look for are Battering Uulgraft with Return to Dust Level 30 and Molten Xophgraft with Heart of Flame Level 30.

Return to dust slams down uniques/rares with a decently damaging attack

Heart of Flame will give you a buff that absorbs around 4500 damage!

Future Upgrades:

Lightning Coil converts physical damage into lightning damage meaning it is dampened down by our lightning resistance (physical damage suppression requires armour which we don't have in this build so you need a way of reducing physical damage). Make sure you have a Topaz Flask (replace Silver Flask) with the automated enchant to make up for the -60% lightning resistance affix.

Passive Tree

main:
123
123
ascendancy:
8
8
Masteries
Life Mastery (2)
+30 to maximum Life
15% increased maximum Life if there are no Life Modifiers on Equipped Body Armour
Poison Mastery (2)
Poisons you inflict on non-Poisoned Enemies deal 300% increased Damage
Enemies Poisoned by you cannot deal Critical Strikes
Evasion Mastery (1)
100% increased Evasion Rating from Equipped Body Armour
Leech Mastery (1)
5% of Leech is Instant
Flask Mastery (1)
Life Flasks gain 1 Charge every 3 seconds
Mana Flasks gain 1 Charge every 3 seconds
Mana Mastery (1)
12% increased Mana Reservation Efficiency of Skills
Projectile Mastery (1)
Projectiles deal 20% increased Damage with Hits and Ailments for each time they have Chained
Reservation Mastery (1)
8% increased Damage for each of your Aura or Herald Skills affecting you
Accuracy Mastery (1)
+500 to Accuracy Rating
-2 to Accuracy Rating per Level
Spell Suppression Mastery (1)
Prevent +3% of Suppressed Spell Damage

Mastery Changes from Levelling/Earlygame

You should have 100% chance for spell suppression now - so change mastery to 'prevent +3% of suppressed spell damage'.

Change Evasion Mastery to 100% increased evasion from body armour as we now have Asenath's Gentle Touch which is an energy shield base - we cannot benefit from +15% spell suppression chance

Jewels

All small jewel slots should be filled with Viridian Jewels with Chaos Damage Multiplier, +All Elemental Resistances

We also get Large Cluster Jewel with 8 passives and 1 added passive skill is Unwaveringly Evil, 1 passive skill is Wicked Pall and 1 passive skill is either Unholy Grace or Unspeakable Gifts. The cheaper on trade is Unholy Grace, it doesn't matter which one you get.

This allows us to add x2 Medium Cluster Jewel both with adds 4 passive skills and 2 affixes

The first one should have Follow-Through and Repeater

1) Follow-Through works on our poison damage over time and is a massive DPS increase.

2) Repeater isn't great but is a decent second affix to look for.

The second one should have

1) Spiked Concoction which will help with flask charge generation and

2) Mender's Wellspring,  Special Reserve, Brewed for Potency, Peak Vigour or Distilled Perfection. Whichever combo is cheapest!

Skills

Fate Coat
Syndicate's Garb
Poisonous Concoction of Bouncing
Greater Multiple Projectiles
Greater Volley
Unbound Ailments
Void Manipulation
Deadly Ailments
Asenath's Gentle Touch
Silk Gloves
Summon Chaos Golem
Cast when Damage Taken
Meat Shield
Minion Life
Agony Crest
Silken Hood
Purity of Elements
Grace
Herald of Agony
Frostblink
Leper's Alms
Mirrored Spiked Shield
Shield Charge
Faster Attacks
Momentum
Earlygame Boots
Velour Boots
Steelskin
Automation
Blood Rage

Temporal Chains is provided intrinsically by Asenath's Gentle Touch - you do not need to socket!


Obtaining Poisonous Concoction of Bouncing can be done in two methods:

1) Buy it from trade website

2) Keep running the Third Lab until you get the designated upgrade from the Divine Font (there is a low chance of you obtaining it from earlier labs so always keep a spare green gem ready)

How it Plays

Pre-Level 12

1) Spam Caustic Arrow whilst running around and Mirage Archer Support will kill off enemies

2) Use Burning Arrow if needed for stronger bosses

Post Level 12

1) Swap to Poisonous Concoction which scales off the life value of your life flask

2) We use Shield Charge and Frostblink to traverse the map at crazy speed

3) Buffs like Grace and Purity of Elements provide a good defensive layer

4) Withering Step, Temporal Chains are used on bosses

Endgame

1) Spam Poisonous Concoction of Bouncing - Blood Rage, Herald of Agony add even more damage!

2) We use Shield Charge and Frostblink to traverse the map at crazy speed

3) Buffs like Grace, Purity of Elements, Steelskin provide a good defensive layer

Be sure to check out Skills Section For Full Links!


How it Works

Levelling Guide

Vendor Search (Regex)

Copy below into the vendor search bar to highlight useful early gear (shows 4-Links, GGG, GG, MS Boots, Quivers & Bows)

-\w-.-|g-g|nne|rint|s:.+bow|s:.+qu phys|

Act 1

Level 1

Take Caustic Arrow from the quest reward and link it with Momentum.

Level 4

Take Mirage Archer from Nessa.

Take Sniper’s Mark and Dash from Tarkleigh.

Buy Pierce from Nessa.

Link setup: Caustic Arrow – Mirage Archer – Pierce.

Use Sniper’s Mark on Rares and Bosses for extra DPS.

Use Dash as your main movement skill (use it on cooldown).

Level 8

Replace Caustic Arrow with Burning Arrow in your links. Use this setup to kill Brutus.

Take Void Manipulation from Nessa’s quest reward and socket it to level it for later use.

Take Precision from Tarkleigh’s quest reward and activate it once you can. Keep it around level 3 to avoid mana issues.

Buy Frostblink from Nessa and replace Dash with it. Keep Frostblink at level 3 or below (higher levels require more Intelligence).

Level 12

Swap to Poisonous Concoction. Nessa will reward you with one when you first enter Merveil’s Caverns.

Try to reach level 12 before fighting Merveil so you can use Poisonous Concoction with decent life flasks and Withering Step to melt her quickly.

In Town:

Buy Volley, Withering Step, Shield Charge, and Faster Attacks from Nessa.

Your main link setup should now be:

Poisonous Concoction – Void Manipulation – Volley

If you don’t have the colors for the full 3-link, just run Poisonous Concoction – Volley.

Remove your bow and equip a shield (preferably one with movement speed).

Drop Caustic Arrow, Mirage Archer, and Pierce.

Keep and use: Frostblink, Shield Charge, Sniper’s Mark, Withering Step, and Poisonous Concoction.

Use Withering Step to apply Wither to bosses — otherwise, avoid using it since it shares a cooldown with Frostblink.


Act 2

Bandit Choice:

Help Alira. The +15% Elemental Resistances is very helpful for league starting.

Later, once your gear improves in early maps, you can switch to Eramir for +1 Passive Point.

Level 16

Take Herald of Agony as your quest reward from Greust.

Buy Blood Rage from Yenna.

Level 20

After defeating The Weaver, take Vicious Projectiles from Silk.
Socket it somewhere so it can gain experience — this gem will later become part of your 4-Link setup for Poisonous Concoction.


Act 3

Preparing Your Links

Begin searching for the following socket colors:

  • GGGG – for Poisonous Concoction – Lesser Multiple Projectiles – Void Manipulation – Vicious Projectiles
  • GGGB – to use later in Act 6, where you’ll replace Vicious Projectiles with Unbound Ailments (purchased from Lilly).

For movement:

  • Aim for RGG to link Shield Charge – Faster Attacks – Momentum.
    • You can buy Momentum from Nessa in Act 1 when you have an available slot.

Auras and Curses

  • Take Grace from Clarissa’s quest reward.
  • Buy Temporal Chains and Purity of Elements from her as well.
  • Run Purity of Elements alongside Herald of Agony for now — these will be your two main auras.
  • Keep Grace socketed so it can level up; you’ll activate it in Act 6 once you’ve allocated Charisma and Thrill of Battle along with their Mana Mastery.

Replace Sniper’s Mark with Temporal Chains. Use Temporal Chains as your curse for Rares and Bosses going forward.

You can skip the Library and Siosa’s quest — any missing gems can be purchased from Lilly in Act 6.


Act 4

Before doing your first Labyrinth, return to Act 1 and purchase another Poisonous Concoction from Nessa.
After completing the Lab, you’ll gain access to The Divine Font, which allows you to transform a skill gem into a Transfigured version of the same color.
Use this on your spare Poisonous Concoction and hope for the Poisonous Concoction of Bouncing variant.

Starting with the Act 10 Labyrinth, there’s also a chance to encounter an option that lets you instantly transfigure a gem — this can directly grant PConc of Bouncing, which is the superior version of the skill.

Do the Lab around level 31 when your gems have upgraded.
If you’re worried about surviving Izaro, disable Purity of Elements and enable Grace instead — his elemental damage is minor compared to his heavy physical attacks.

If you’re lucky enough to obtain PConc of Bouncing, switch to it immediately.
This version throws a single flask that bounces multiple times, scaling with your additional projectiles. It conserves flask charges and has a much higher DPS ceiling than the standard PConc.

Once you have Bouncing, upgrade Volley to Greater Volley (available in Act 4) and replace Vicious Projectiles with Greater Multiple Projectiles for even more coverage.

If you don’t get PConc of Bouncing while leveling, don’t worry — it’s easy to target farm later once you reach Maps.


Act 6

In this act, allocate Charisma, Thrill of Battle, and their associated Mana Mastery (for +12% Mana Reservation Efficiency).
With these, you can drop Precision and activate Grace, giving you a huge defensive boost for the rest of the campaign.

Complete Lilly’s Beach Quest as soon as you arrive in Act 6.
From Lilly, purchase:

  • Steelskin
  • Automation
  • Unbound Ailments

At this point, you might not have enough sockets for everything.
If necessary, postpone using Automation and Steelskin until you find more gear with available links.

Once possible, link Steelskin – Automation.
Activate Automation just like an aura — it will automatically trigger Steelskin on cooldown.

Add Unbound Ailments to your Poisonous Concoction setup as soon as you have a 4-Link available.
Until then, just let it level in an unused socket.
Vicious Projectiles is still perfectly viable until you obtain PConc of BouncingUnbound Ailments is only a slight improvement if you already have a GGGB socket.


Act 7

Complete your second Labyrinth here and select Master Toxicist as your next Ascendancy.


Act 10

After rescuing Bannon on the Rooftop, return to town and choose a Silver Flask as your reward.
Once you have this flask, you can safely remove Graceful Assault from your passive tree and allocate those points elsewhere.
If you prefer not to manually maintain the flask for Onslaught, you can keep Graceful Assault until around level 80 — or until you craft the Movement Speed + Onslaught on Kill modifier on boots, which you should swap to immediately.

Before fighting Kitava, complete your third Labyrinth and take Nature’s Adrenaline.
This greatly improves flask uptime and prepares you for using Replica Sorrow of the Divine later.

Make sure to finish the Lab before facing Kitava, since the final boss fight becomes much harder after the −30% Elemental Resistance penalty.

Changelog

9/11 - Upgraded for Endgame

29/10 - Initial Starter Guide for 3.27

Video Guide

Stats

Stats are displayed for the "Endgame" Variant only
Character
Attributes
145 / 
294 / 
176
Movement Speed
221%
Charges
Endurance Charges
3
Frenzy Charges
4
Power Charges
3
Defensive
Life
4,022
Energy Shield
369
Mana
878
Armour
0
Evasion Rating
40,757
Block
30%
Resistances
75% / 
75% / 
75% / 
50%
Simulated
Effective Health Pool
30K
Max Hit
5.5K / 
20K / 
20K / 
20K / 
11K
Skill DPS Estimation
Poisonous Concoction of Bouncing
1.2M

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