As the mother of Zagreus and Melinoë, Persephone bestows upon Mel her motherly love through her Revaal Aspect.
The Aspect of Persephone grants a Bonus level to a random Boon every time you are offered one. Naturally, this means that Gods with Boons that scale up well with Boon levels are the perfect fit when wielding this Aspect.
On the run this build is based off of, my very first Hephaestus Boon offering had a lvl 10 Anvil Ring and a lvl 9 Volcanic Strike (2 sec recharge time).
For this reason, I suggest sticking to the core of this build as much as possible when using Aspect of Persephone. I'll cover everything in greater detail below, including variations, substitutes, dealing with poor RNG.
Full Build
Weapon Aspect
Weapon AspectAspect of Persephone
Arcana Loadout
Keepsakes
Starting KeepsakeJeweled Pom
KeepsakeTime Piece
KeepsakeKnuckle Bones
KeepsakeEngraved Pin
Animal Familiar
Animal FamiliarToula
Hex
HexWolf Howl
High Priority Boons
God Pool
Core Boons
Secondary Boons
Hermes Boons
Legendary / Duo Boons
Daedalus Hammer Upgrades
NPC Offerings
Poms of Power
Volcanic Strike is the primary target for this build. Smithy Rush and Volcanic Flourish can also work as long as you have the Boon level. But it's definitely easier to get consistent and safe value from the Attack here.
For the remaining Gods, I like Ares to get Grievous Blow and Mutual Destruction for % chance to deal +200% damage on every Hephaestus Blast.
Hestia is good for damage over time from Scorch, and activating Origination (XIV) before you get Furnace Blast. Their duo Chain Reaction can double your blast damage by firing twice as well.
However, Demeter and Apollo Duo Boons (Cryo Pounder &Rude Awakening) are also very strong, making them good additions to your God pool.
Starting Loadout
Persephone Skulls
The two mechanics of Aspect of Persephone is the +Boon levels mentioned in the intro, and Sprouted, which I'll cover here.
To explain how the +Boon levels functions more precisely, every time Melinoë is offered a Boon, randomly selected Boons will have +Boon levels.
The rank of your Aspect of Persephone, determines the MAXIMUM increased Boon level that can be offered to you. It does not mean every Boon will have +level or that every +level Boon will be (+6).
In the above image, you'll see that both Volcanic Strike and Anvil Ring are being offered at an extremely high Boon level. Jeweled Pom set every Boon at lvl 4, then Aspect of Persephone randomly selected two Boons, and increased them by +5 and +6.
Sprouted
First off, Olympian Damage is generally Boon damage listed as a flat value. For example, Scorch from Smolder Ring is listed as "40" damage at Common. Scorch itself deals 100 damage per sec, and that is also Olympian Damage.
In contrast, Ice Strike causes your attack to deal +30% damage. That is weapon damage and NOT Olympian damage.
Max Sprouted
To reach Max Sprouted, you need to deal 2000 Olympian damage. Then your Omega Special will last for a full 2 seconds.
This is further reasoning why Hephaestus pairs so well with Aspect of Persephone. You are constantly dealing high amounts of Olympian damage, which results in Sprouted being available pretty much anytime you want it.
Keepsakes
You can either start with Adamant Shard to guarantee Hephaestus, or the much more powerful approach is the start with Jeweled Pom because the two +lvl effects stack with each other.
Trading RNG for +Boon levels pays off big if Hephaestus is naturally offered to you. Even if he isn't, taking any lvl 10 Boon is going to be extremely powerful. The most random builds with terrible synergy work with Aspect of Persephone and Jeweled Pom simply because the level of everything is so high.
Victory Screen
40 Fear on the Surface
As you can see, Hephaestus blasts always go big with a Jeweled Pom and Aspect of Persephone start. Even if I was only offered his Dash, Smithy Rush, I'd still take it for Glow and secondary/duo Boon buffs.
Revaal (Argent Skull)
Aspect of Persephone (Skull)
Zagreus and 
Melinoë, 
Persephone bestows upon Mel her motherly love through her 
Revaal Aspect.
Aspect of Persephone grants a Bonus level to a random Boon every time you are offered one. Naturally, this means that Gods with Boons that scale up well with Boon levels are the perfect fit when wielding this Aspect. 
Hephaestus Boon offering had a lvl 10 
Anvil Ring and a lvl 9 
Volcanic Strike (2 sec recharge time).
