We're ranking all 25 heroes based on their viability in Red Rifts. If you're playing on any of the Endless difficulties, take these rankings with a grain of salt. After all, team size is a much lower priority when funds are limited and death count matters.
Heroes will be ordered based on how frequently they can be used overall (from C to S). Those who fulfill a wider range of roles, such as helping in both Act 1 and Act 2, will generally be rated higher. However, there may be cases where a hero's limited performance is so strong that it justifies a higher placement.
All that said, Guildrun is patched frequently, so expect things to change.
S-Tier: The over-performers. These heroes stand out in terms of power and utility, often acting as a key component of many teams, regardless of synergies. Low commitment, high payoff.
A-Tier: Strong heroes that are generally flexible and well worth investing into. They excel in their role, and have the potential to carry you through the early, mid, and/or late game (usually 2 of 3).
B-Tier: Important role players that either define their archetype, or shine during a particular phase of the run. They aren't far behind in power level, but generally require more item investment and/or synergies.
C-Tier: Solid but situational. Heroes in this tier often lack utility compared to the others of their class, or require optimal timing in order to stand out. They can still work, but have less common use cases.
D-Tier: Extremely niche. While their power ceiling may be high, they can be difficult to use compared to other heroes. Often purchasable at higher ranks, but rarely a go-to choice early on.