This Street Brawl Tier List covers the rankings of every Deadlock hero and organizes them by tier from best to worst in the mode. We'll also include meta commentary on which items and kits are most impactful and why.
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Quick Rankings
S+ Tier (Meta-Defining)
S-tier
A-tier
B-tier
C-tier
D-tier
Items and General Practicality
Important Mechanics
Enhanced Items carry over during their upgrade.
For example, if you manage to get enhanced 
Healing Rite, the game will very likely offer Enhanced 
Healing Nova or 
Rescue Beam.
Also that the tier of items will stay the same across rerolls, so Legendary Items like Celestial Blessing (Tier 5) will always reroll into another legendary items.
and that enhanced items will always reroll into another enhanced item of the same tier.
The best Legendary Items currently are Celestial Blessing, Infinite Rounds, and Shrink Ray. ALWAYS PICK THESE ITEMS WHEN OFFERED.
Keep a look out for certain enhanced items such as Rescue Beam or 
Majestic Leap and 
Veil Walker. These are always recommended to be AUTO-PICKS.
Remember that a Core Item for the character you're playing will usually be better then a bad enhanced item.
For Example, 
Berserker on 
Lady Geist will always be better then an enhanced 
Burst Fire.
Explanations
S Tier
Paige is the best hero in Street Brawl, has great AoE and damage and also has access to more better draws including the Support items like Rescue Beam.
The S-Tier's perform the best and consistently perform despite bad draws and are well suited for the 4v4 nature fighting of the Brawl.
That means they are more likely to find items that are usable for their character and can avoid bad items with rerolls or can pivot easier to a different variant of their build.
They also have the best teamfighting utility and damage compared to the rest of the cast such as 
Graves's 
Borrowed Decree or 
McGinnis's 
Medicinal Specter.
A Tier
These heroes perform consistently but get generally statchecked by the S-Tiers and typically have a solid weakness that lets them get outmaneuvered.
The heroes in this tier are generally favored but can have a tough time when facing against strong counter choices like 
Dispel Magic or 
Spellbreaker or an enhanced 
Disarming Hex.
B Tier
The heroes in his tier need specific items to function and can be impossible to find. While they are able to have strong games, they need to be continuously lucky to find good items and typically only have 1 core way of playing the Brawls.
For example, 
Lash might have a difficult time if he cannot find mobility items like 
Warp Stone or Majestic Leap and can easily be counter by other heroes like 
Vindicta or a lucky counter-item like 
Knockdown.
C Tier
These heroes struggle the most and require very premier draws and are not very well suited for Street Brawl. Even with lucky draws they will still struggle against anyone in the game and are not recommended to be picked.
For example, 
Kelvin and 
Yamato are not ideal against large groups of enemies and have cooldowns that are too long for each round. 
Frozen Shelter and 
Shadow Transformation both only get 1 use during each round and can be very hard to capitalize off of.
D Tier (Doorman and Silver)
Doorman is very weak in Street Brawl as he extremely unsuited for brawl fighting and 
Doorway and 
Hotel Guest is completely pointless in Brawl.
Silver is limited in range and has a very difficult time closing the distance against the entire roster. It is simply too difficult to go launch herself into the lane. She also lacks a powerful gun or having good Spirit scaling nor does her AP points help very much when it comes to the later rounds.