Kripp's Self-Poison Mak Build

Core Synergies

• Life Conduit is the ideal Quest Relic to pickup during the early game. Completing its Quests will unlock a tremendous power spike for the mid game.
• Idol of Decay is another great choice to invest into, giving the build a much faster clock thanks to its Poison scaling.
• Nightshade and Aludel are both reasonable inclusions for the early days, before your Quest items are online.
• Emerald and Fungal Spores help boost Aludel, whereas Nightshade works best with Small Regen items.
• Barbed Claws + Shadowed Cloak is a solid early game combo alongside Damage skills.

Tips & Tricks

• Spider Mace is incredible with the right setup and works wonders in multiples. It won't be great initially, but it unlocks great power in the mid to late game.
• Mothmeal and Hemlock are the ideal Reagents, giving you a chance at getting a Heavy/Toxic Spider Mace, among other things.
• Peacewrought is a great source of income alongside Catalyst generators like Aludel and Mortar & Pestle. Always upgrade it to Silver ASAP.

Common Filler Items

• Incense
• Leeches
• Myrrh
• Noxious Potion
• Philosopher's Stone
• Thurible
• Quill and Ink
• Venom
• Venomander
• Venomous Dose

Core Synergies

• Adrenal Converter + Rapid Injection System is the quintessential combo for generating an absurd amount of Poison/Regen triggers.
• Wild Quillback is an alternative to Rapid Injection System, generally utilized in non-Weapon setups.
• Excavation Tools is a worthy slot-in for its acceleration, provided you have at least one of the Quest Relics.
• Runic Potion provides sustain primarily for the Spider Mace setups, but works best with efficient Damage scaling skills like Toxicity.
• Ouroboros Statue is a reasonable replacement for Life Conduit during the early to mid game, but will usually be replaced later on.

Tips & Tricks

• Be careful about adding any Poison scaling (or skills) early on, at least until your Regen far exceeds your self-inflicted Poison.
• The Tome of Yyahan and Sifting Pan can let you stack out-of-combat Regen, helping to enable some alternative paths in the late game.
• Enchantments can greatly define the build's late game potential. Shielded gives you a chance against one-shot builds, which hard counter the Regen game plan.
• If you lack extra defenses and your clock isn't fast enough, keep an eye out for Regen conversion items (see examples under End Game Build Breakdown).

Core Synergies

• Adrenal Converter + Rapid Injection System + Life Conduit is the popular core for Poison/Regen triggers.
• Spider Mace is common source of fast triggers alongside Rapid Injection System. Power varies greatly depending on available skills/enchantments.
• Soul Ring (or Sunlight Spear) provides a way to convert the massive Regen directly into offense. Generally best with Life Conduit.
• Idol of Decay leans more into the Poison scaling plan, but can be rather frail without a Shielded enchantment.
• • On the other hand, if you're lucky enough to find Barbspike Warden, it's often fast enough to simply race without need for extra defenses.

Tips & Tricks

• Self-Poison is a pretty flexible archetype as long as you have at least a few of its key components. Mak's access to enchants often leads to contextual setups.
• Vital Renewal is a high priority skill for every setup, so you'll often want to reroll for it whenever possible.

Situational Variants

• Staff of the Moose is great alternative similar to Soul Ring and Sunlight Spear, but works best when you've previously stacked out-of-combat Regen.