Augmented Weaponry
The true reason to play weapons on Vanessa in the current patch. Alongside Skills like Lifting, Augmented Weaponry can take over the game as it is now an aura Skill that affects the whole board instead of just one item.
Since this Skill functions as an aura now allows you to pivot from early game Weapons into much better ones found later on in the run while not losing any of the scaling.
The main advantage of this skill is how early you get a hold of it. The Tent City Mayor PvE fight can only occur on Day 2 in a run and the skill is much better than silver Lifting, which is often found only a couple days later when it’s already kinda late to get a good build going due to the heavy economy demand.
Due to any small items will work with Augmented Weaponry, there are a lot of free events that will become high priority and enable good economy to buy every single small Item from vendors throughout the run.
Chocolate Bar, Gumballs, Spare Change, anything goes with this. There’s also a very high synergy between this build and Cove, and you should try to get your hands on one as early as possible.
Alacrity + Flurry of Blows
Once you get your hands on Augmented Weaponry, there’s no need to dig for Skills until Day 7, when Gold tier Skills become normal to appear. Ideally, you want to pick up skills that scale well with Weapons and Critical Strikes.
Alacrity and Flurry of Blows's Charge will help increase the upfront burst damage dealt to enemies before most defenses like Shields and Heals start activating. This is because thematically, Weapons will usually get outscaled so you want as much damage as possible as early as possible so your opponent can’t Freeze or outsustain your DPS.