For leveling and Early Game, check out this build

There's currently a "feature" if you use keyboard movement where you can cast while moving. You need to lead your character spam click to cast, all while making sure your cursor doesn't hover over an enemy. If done correctly, you will be able to spam Blood Surge while running. For a full breakdown, check out this video guide. https://www.youtube.com/watch?v=XCDJyYXl2MM

If you are having any resource issue you can add Iron Maiden to the build. This will allow your Aspect of Cursed Aura to automatically apply Iron Maiden and proc the resource generation.

This build utilizes the synergy between Cruor's Embrace and Hewed Flesh to generate and consume an inane amount of corpses. Thanks to Aspect of the Embalmer when we consume corpses we also spawn Blood Orbs, and by picking those up we both reset the cooldown on Rathma's Vigor and proc Blood Begets Blood.

For Blood Surge to be able to boss efficiently you need a Greater Affix Blood Surge Drains X Additional Times From Elites roll on your Cruor's Embrace gloves with as many master works as possible. This roll double dips into single target damage because the additional drains each add damage and then the nova gets buffed based on how many times the other skills drain.

Cruor's Embrace: One of the most powerful uniques in the game for any build. The Blood Surge Drains Additional Times From Elites is absurdly powerful, and the corpse consumption from the passive is vital to the engine of this build.   Heir of Perdition: This Mythic Unique gives a 60% damage multiplier as well as some good stats in the form of Crit Chance, Movement Speed, and Lucky Hit Chance.   Shroud of False Death: 1 to all passives as well as a high HP and all stat roll makes this item give way too much tankiness and damage to pass up.   Ring of Starless Skies: This Mythic gives more damage than any other available option while also giving 50% resource cost reduction and a nice lucky hit roll. Cannot pass this up.  

Ring of Starless Skies > Heir of Perdition > Shroud of False Death

With the abundance of herbs now in the game it is now very easy to grab some consumables to either shore up big weakness with your character or to massively increase your strengths. I highly recommend you regularly keep Elixirs and Incenses running. Below I laid out the best consumables to use for every situation.  

Elixirs

If you need more of any specific resistance or armor, use those elixirs first. Once your armor capped and resistance capped, look to use the Elixir of Advantage for the extra attack speed. If you're having trouble staying alive and your armor capped and resistance capped, you can use the Elixir of Fortitude to gain a 20% hp multiplier.  

Incenses

For incense you have a couple of options, depending on what your character needs.

Core Stat

• Sage's Whisper: Generally the best option as it gives the most amount of damage.
• Spiral Morning: Not a bad alternative, as the all stat gives some armor and also helps hit breakpoints in paragon tree. Only use if there's specific paragon nodes you're trying to reach.  

Resistance

• Soothing Spices: Best all around option as it gives +10% all resistances and +2% max resistance to everything. Only use another option if needed to hit resistance caps.  

Defensive

• Song of the Mountain: Great early game option for the +300 Armor
• Reddamine Buzz: Gives +750hp, best option if you are already armor capped.

Always make sure you have 1000 armor and 75% all resistances as your number one defensive priority!

Our defense is highly reliant on our skill tree and paragon board. Stand Alone from our passive tree is the single strongest defensive passive in the entire game. We also generate lots of barrier from Necrotic Fortitude due to dealing so many instances of damage, leading to high amounts of Lucky Hit procs. In this vein, we are also able to generate all of our Fortify from a combination of Necrotic Carapace and Hewed Flesh.

From the paragon board we get lots of maximum life percentage, making it very important to get Maximum Life rolls on gear as these two things scale well together. We are also getting lots of damage reduction from Scent of Death and the other damage reduction nodes on that board. Finally, we get access to Damage Reduction While Fortified nodes from the Bloodbath board.

All in all this build is wildy tanky, and can clear the hardest content with ease.

Brawn Over Brains is a gigantic damage increase while also giving some survivability. Defile the Dead is insanely powerful as it enable our Cruor's Embrace to deal way more damage and generate way more Blood Orbs. Crazy Brew and Accelerating Chaos are both minor buffs that we are taking because there's not much better.

Masterworking

Masterworking (MW) enhances an item's stats. Each MW rank boosts all affixes by 5%. Ranks 4,8,12 give a 25% bonus to a random affix (MW Crit).

In this planner, the color blue on an item denotes that the affix got one MW Crit, the color yellow denotes that the item got two MW crits and the color orange denotes that the item got three MW crits.

For future reference the amount of MW Crits on an affix will be denoted by 1MW, 2MW, 3MW.

Greater Affixes

Greater Affixes (GA) on an item force the affix to roll at the top of it's range of possible values and then applies a 50% increase to its value. GA increases are additive with Masterworking increases.

In this planner, the yellow star to the left of an affix denotes that is a GA.

Example

To put it all in to practice, let's calculate what stat increase a GA Affix on a 12/12 Masterworked item with 2 MW Crits gets:

Ranks 1-3, 5-7, 9-11 all give 5% -> 9 * 5% = 45%

Two MW Crits -> 2 * 25% = 50%

GA = 50%

Total = 45% + 50% + 50% = 145%

9/19: Updated for Season 10 10/8: Updated for Patch 2.4.1